前列腺癌大分割调强放疗副反应的近期观察  

Observation on the Recent Side Effects of Hypofractionated Intensity-modulated Radiotherapy for Prostate Cancer

作　　者：郝云飞[1,2] 陈明晓[3] 任俊丽[3] 王艳萍[3] 范立[3] 

机构地区：[1]山西医科大学研究生学院,山西太原030001 [2]山西医科大学 [3]山西省肿瘤医院放疗五科,山西太原030013

出　　处：《中国现代医生》2011年第13期15-16,20,共3页China Modern Doctor

摘　　要：目的初步探讨大分割调强放疗(IMRT,70Gy/28次/6周)与常规调强放疗(78Gy/39次/8周)治疗前列腺癌的早发和迟发性毒副作用和疗效。方法 2005～2010年间,我院有27例前列腺癌患者接受大分割调强放疗,30例前列腺癌患者接受常规调强放疗,其中18例患者的临床靶体积(CTV)包括前列腺、精囊及盆腔淋巴引流区,39例包括前列腺及精囊。结果大分割组和常规组1～3级急性泌尿系毒性反应发生率分别为74%和70%;急性直肠毒性反应发生率分别为67%和67%;1～3级迟发性泌尿系毒性反应发生率分别为41%和40%,迟发性直肠毒性反应为41%和37%。两组的3年无生化失败生存率(bNED)分别为75%和78%(χ2=0.151,P=0.697>0.05)。结论高剂量大分割调强放疗治疗前列腺癌是可行的,泌尿系和直肠毒性反应可接受。Objective To investigate toxic side effect and efficacy of hypofractionated intensity-modulated radiotherapy（IMRT,70Gy/28/6 weeks） compared with conventional fractionated intensity-modulated radiotherapy （78Gy/39/8 weeks）. Methods During 2005 to 2010,27 patients with prostate cancer received hypofractionated IMRT while other 30 cases were treated with conventional fractionated IMRT. Clinical target volume（CTV） was the prostate, seminal vesicle and pelvic lymph nodes in 18 patients and the prostate and seminal in 39 cases. Results Grade 1 and 3 acute genitourinary,rectal,late genitourinary and rectal toxicity occurred in 74%,67%,41% and 41% patients in hypofractionated groups and 70%,67%,40% and 37% in conventional groups. The 3-year biochemically no evidence of disease （bNED） was 75% and 78% in hypofractionated and conventional group,respectively（ X2=0.151,P=-0.697〉0.05）. Conclusion It is feasi- ble for hypofraetionated IMRT for the treatment of prostate cancer with low incidence of genitourinary and rectal toxicity.

关 键 词：前列腺肿瘤 调强 大分割放射疗法 副反应 

分 类 号：R730.55[医药卫生—肿瘤]