帕罗西汀联合再普乐治疗抑郁症60例  

The Treatment of 60 Cases of Depression by Using Paroxetine Combinde Zyprexa

作　　者：陈德沈 章飞雪 李方敏 台勇 叶洁华 

机构地区：[1]温州康宁医院精神科,浙江温州325007

出　　处：《中国现代医生》2011年第13期29-30,共2页China Modern Doctor

基　　金：浙江省温州市医药卫生科研项目(编号:2006A062)

摘　　要：目的探讨帕罗西汀联合再普乐治疗抑郁症的临床疗效。方法将120例抑郁症患者随机分为对照组和治疗组,每组60例。对照组给予帕罗西汀单独治疗;治疗组在对照组基础上加用再普乐治疗,连续治疗8周,治疗前和治疗后用汉密顿抑郁量表(HAMD)和焦虑量表(HAMA)评分,评价临床疗效并观察不良反应发生情况。结果治疗8周后,治疗组的HAMA和HAMD评分均显著低于对照组(t=2.72,P=0.028和t=2.85,P=0.021);治疗组的显效率和总有效率为70.0%、85.0%,均分别高于对照组的51.7%和71.7%(χ2=2.23,P=0.017和χ2=2.15,P=0.019);治疗组的不良反应发生率与对照组比较无统计学意义(χ2=0.42,P=0.836)。结论帕罗西汀联合再普乐治疗抑郁症的疗效确切,且不良反应无显著增加,值得临床推广应用。Objective To investigate the clinical effect of Zyprexa and Paroxetine on treatment of depression. Methods 120 patients with depression were randomly divided into control group and treatment group,and 60 patients in each group. The control group was only given Paroxetine while the treatment group was treated with Zyprexa and Paroxetine. Both of them were cured for 8 weeks contin- uously and recorded the scores of Hamilton Depression Rating Scale （HAMD） and Hamilton Anxiety Scale （HAMA） before and after treatment,then evaluate the clinical effect and the adverse reactions after the treatment. Results After 8 weeks,the scores of HAMA and HAMD in the treatment group were significantly lower than the control group（t=2.72,P=-0.028 and t=2.85 ,P=0.021 ）;The excellence and total effective rate in the treatment group were 70.0%,85.0%,which were higher than 51.7% and 71.7% in the control group（ X2=2-23, P=-0.017 and X2-=-2.15,P=0.019）;There was no significant difference in the incidence of adverse reactions between two group（ X2=0.42, P=0.836）. Conchlsion The treatment of depression by using Zyprexa and Paroxetine is effective, and it is no significantly increase in the adverse reactions, which should be widely applied.

关 键 词：帕罗西汀 再普乐 抑郁症 

分 类 号：R749.41[医药卫生—神经病学与精神病学]