高频超声检测脑梗死与短暂性脑缺血发作患者血管内皮功能的探讨  

Investigation on High Frequency Ultrasound in Detection of Vascular Endothelial Function in Patients With Cerebral Infarction and Transient Ischemic Attack

作　　者：王少特[1] 范晓梅[1] 李莉[1] 雷志辉[1] 

机构地区：[1]武警湖北总队医院,武汉430061

出　　处：《内科急危重症杂志》2011年第2期102-104,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:研究脑梗死、短暂性脑缺血发作(TIA)患者颈动脉内-中膜厚度、血管弹性与肱动脉血管内皮功能。方法:研究对象分为3组:脑梗死患者、TIA患者、正常同龄人,每组各30例。用高频超声测量颈动脉内-中膜厚度、收缩期颈动脉内径(DS)、舒张期颈动脉内径(DD),计算颈总动脉壁弹性的相关参数:可扩张度(DC)、顺应性(CC),观察受检者的肱动脉充血反应性扩张(DTRH)和含服硝酸甘油后血管内径的变化(DTNG),并进行对比分析。结果:脑梗死患者颈动脉内-中膜厚度较TIA患者、正常对照组增厚(P<0.01)、血管弹性与血管内皮功能明显减低(P<0.01),TIA患者较正常对照组血管内皮功能明显减低(P<0.01),血管内皮功能与颈动脉内-中膜厚度之间呈负相关,与颈总动脉壁可扩张度、顺应性之间呈正相关。结论:肱动脉依赖性血管内皮细胞功能与颈总动脉内中膜厚度、血管弹性可作为监测脑梗死、TIA患者治疗及判断预后的指标。Objective：To study the intima-media thickness（IMT）,vascular elasticity and the vascular endothelial function in patients with cerebral infarction and transient ischemic attack（TIA）.Methods：Subjects were divided into three groups：cerebral infarction group,TIA group and normal volunteers with the same age,30 cases for each group.IMT,systolic diameter（SD）and diastolic diameter（DD）of the carotid atery were measured with high-frequency ultrasound,the parameters of elastic properties were calculated,such as distensibility,compliance of common carotid artery（CCA）.Subject＇s dilation of the brachial artery to reactive hyperemia（DTRH）and the dilation to sublingual nitroglycerin administration（DTNG）were observed and compared.Results：As compared with TIA and normal group,the IMT of cerebral infarction was increased（P0.01）,vascular elasticity and vascular endothelial function were reduced significantly（P0.01）.As compared with the normal group,the vascular endothelial function of TIA was reduced significantly（P0.01）.The vascular endothelial function was negatively correlated with the IMT,but positively correlated with distensibility and conformability of CCA.Conclusions：Brachial artery dependend endothelial function,IMT of CCA and vascular elasticity can be indicators for treatment and prognosis of patients with cerebral infarction and TIA.

关 键 词：脑梗死 内-中膜厚度 血管弹性 血管内皮功能 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R743.33[医药卫生—临床医学]