OX40对CD4记忆T细胞的调节  

Regulation of CD4 Memory T Cells by OX40

作　　者：王立英[1] 王玉亮[1] 

机构地区：[1]天津医科大学一中心临床学院卫生部危重病急救医学重点实验室,天津300192

出　　处：《透析与人工器官》2011年第1期44-46,共3页Chinese Journal of Dialysis and Artificial Organs

摘　　要：CD4记忆T细胞在保护机体免受病毒、细菌、寄生虫等物质感染中起十分重要的作用,并与自身免疫反应、变态反应等有关异常的免疫反应相关。理解免疫记忆反应有效的控制机制对于疫苗的设计以及调控异常免疫反应有着重要的意义。近年来,肿瘤坏死因子受体超家族成员-OX40(CD134),作为一共刺激分子对于维持CD4+T细胞的活化、增值、存活起到关键性作用。本文对此研究进展作以综述。CD4 memory T cells play an important role in protecting against repeated exposure to infectious agents such as viruses,bacteria,and helminth parasites,and also can contribute to the aberrant immune responses with autoimmune and allergic reactions.Understanding the mechanisms that control effective memory responses has important significance for vaccine design and in the management of adverse immune reactions.In recent years,tumor necrosis factor receptor（TNFR） family member-OX40（CD134）,as a key co-stimulatory molecule,involved in maintenance of activation,proliferation,survival of CD4＋ T cells.This paper makes a review on this investigation study.

关 键 词：CD4T细胞 记忆 共刺激 OX40 OX40L 

分 类 号：R392.4[医药卫生—免疫学]