supported by the National Natural Science Foundation of China(Nos.82172335,81971994,91846103,and 81871709);the Zhejiang Provincial Key Research and Development Program(No.2020C03032),China.
Immune thrombocytopenia(ITP)is a hemorrhagic autoimmune disease characterized by antibody-mediated platelet injury.ITP has complicated immunopathological mechanisms that need further elucidation.It is well known that ...
t OX40 is a costimulatory receptor that is expressed primarily on activated CD4+,CD8+,and regulatory T cells.The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion,differentiation,and activation an...
This work was financially supported by the National Key R&D Program of China(2021YFB3800900);National Natural Science Foundation of China(51925305,51873208,51833010,51803210,51973217);Jilin province science and technology development program(20200201075JC).
The low objective response rates and severe side effects largely limit the clinical outcomes of immune checkpoint blockade(ICB)therapy.Here,a tumor“self-killing”therapy based on gene-guided OX40L anchoring to tumor ...