番茄红素对血液透析患者静脉铁剂诱导细胞因子的影响  

Effects of lycopene on Cytokine Induced by Intravenous Iron in Maintenance Hemodialysis Patients

作　　者：金领微[1] 郑育[1] 叶菡洋[1] 周志宏[1] 李占园[1] 陈辉乐[1] 毛朝鸣[1] 戴彩香[1] 杨筱敏[1] 

机构地区：[1]温州医学院附属第二医院肾内科,温州325088

出　　处：《中国中西医结合肾病杂志》2011年第1期40-42,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：温州市科技局基金资助项目(No.Y2008046)

摘　　要：目的:观察维持性血液透析(MHD)患者由静脉铁剂诱导的细胞因子,探讨番茄红素对其的干预作用。方法:60例MHD患者,随机分为两组(对照组和试验组,各30例)。对照组:在患者透析时给予蔗糖铁注射液100mg,2次/周,共10次,观察时间8周。试验组:除蔗糖铁注射液使用外,同时口服番茄红素胶囊,2粒/次,2次/d,用药8周,观察时间8周。观察并比较两组患者治疗前及治疗8周后的白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、白细胞介素-18(IL-18)、肿瘤坏死因子(TNF-α)等细胞因子指标的变化。结果:两组患者治疗后IL-1β、IL-6、IL-8、TNF-α、IL-18水平较治疗前均有显著性升高(P<0.01或<0.05);但是试验组升高幅度显著性小于对照组(P<0.01)。试验组患者治疗后IL-10水平较治疗前有显著性升高(P<0.01);并且试验组升高幅度显著性大于对照组(P<0.05)。治疗后两组血清IL-1β、IL-6、IL-8、TNF-α、IL-18水平均与铁蛋白(SF)呈正相关(P<0.01)。结论:静脉铁剂治疗加剧了MHD患者免疫细胞因子的调节;番茄红素可减少细胞因子过度调节而起到抗炎症作用。Objective：To observe oxidative stress and inflammation induced by intravenous iron and its prevention by lycopene in maintenance hemodialysis（MHD）patients.Methods：60 MHD patients were randomly divided into two groups：control group（n=30）and treatment group（n=30）.In control group,the patients were treated with iron sucrose,100mg intravenous,during 10 consecutive hemodialysis sessions,twice a week for five weeks.In treatment group,in addition to intravenous iron,the patients were given lycopene,2# oral,twice a day for eight weeks.Their IL-1β,IL-6,IL-8,IL-10,IL-18,TNF-α were measured at pre-and post-treatment.Results：Compared with the pre-treatment,the levels of serum IL-1β,IL-6,IL-8,IL-18 and TNF-α in both groups elevated markedly（P0.01 or 0.05）.but the increament rate of serum L-1β,IL-6,IL-8,IL-18 and TNF-α in treatment group was less than those in control group（P0.01）.Compared with the pre-treatment,the levels of serum IL-10 in treatment groups were elevated significantly（P0.01）.Moreover t the increament rate of IL-10 in treatment group was more than that in control group（P0.05）.At post-treatment,the levels of serum IL-6,IL-8,IL-18 and TNF-α were positively correlated to the levels of SF in both group（P0.01）.Conclusion：Intravenous iron therapy could induce activation of cytokine in MHD patients,which could be alleviated by lycopene.

关 键 词：番茄红素 细胞因子 静脉铁剂 血液透析 

分 类 号：R459.5[医药卫生—治疗学]