首发未服药的精神分裂症患者多导睡眠图特征  

Polysomnographic study in first-episode schizophrenics

作　　者：王俊清[1] 林以环[1] 江丽芸[1] 翁壁兰[1] 许崇涛[1] 卓永宁[1] 章杰[1] 陈曲亮[1] 

机构地区：[1]汕头大学精神卫生中心,汕头515063

出　　处：《中国神经精神疾病杂志》2011年第4期222-225,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省医学科研基金资助项目(编号:A2010415)

摘　　要：目的探索首次发病的精神分裂症患者多导睡眠图(Polysomnography PSG)的特征。方法对22例首发精神分裂症患者和18名正常对照进行整夜PSG监测,采用匹兹堡睡眠质量指数量表评估主观睡眠,比较两组PSG及主客观睡眠的差异。结果与对照组比较,患者组表现入睡潜伏期延长[(67.26±13.02)min vs(28.73±10.47)min],总睡眠时间减少[(271.46±25.14)min vs(357.81±22.83)min]、睡眠效率下降[(61.58±11.62)vs(89.71±9.44)]、睡眠期觉醒时间[(67.84±13.76)min vs(26.94±8.67)min]和觉醒次数[(34.58±9.49)vs(13.46±4.03)]增多、N1期睡眠增加[(81.29±12.41)min vs(39.51±8.63)min],N2期、N3期睡眠减少[(94.23±16.53)min vs(162.84±18.93)min;(39.78±7.64)min vs(84.15±11.39)min],REM睡眠减少[(47.52±7.64)min vs(73.56±9.43)min],上述组间差异均有统计学意义(P<0.05)。与PSG值比较,患者组主观评估睡眠潜伏期延长、睡眠时间减少、睡眠效率下降(P<0.05)。结论首发精神分裂症患者有睡眠连续性和睡眠结构两方面异常,且对失眠有主观夸大特征。Objective To explore the feature of polysomnography（PSG） in acute first-episode schizophrenics.Methods PSG and Pittsburgh Sleep Quality Index Scale（PSQIS） were used to evaluate subjective and objective sleep in twenty-two first-episode schizophrenics（patient group） and 18 normal controls（control group）.Results Compared with control group,the patient group had significantly prolonged sleep latency,shortened total sleep time,decreased sleep efficiency,increased awake time in sleep continuity,and increased N1 stage,decreased N2,N3 and rapid eye movement stage in sleep structure（Ps0.05）.Patients also had subjective sleep disturbances including prolonged sleep latency,shortened total sleep time and decreased sleep efficiency compared with those of objective sleep（P〈0.05）.Conclusions The first-episode schizophrenics have both sleep continuity and sleep structure deficits,and tend to overrate the severity of their insomnia problem.

关 键 词：首发精神分裂症 多导睡眠图 

分 类 号：R749.3[医药卫生—神经病学与精神病学]