FZD10在骨肉瘤组织中的表达及临床意义  

Expression and clinical significance of FZD10 in osteosarcoma

作　　者：宁刚[1] 高杰[1] 杨彤涛[1] 文艳华[1] 杨连甲[1] 范清宇[1] 马保安[1] 

机构地区：[1]第四军医大学唐都医院骨科,西安陕西710038

出　　处：《现代生物医学进展》2011年第8期1472-1475,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金面上项目(81072194)

摘　　要：目的:探讨骨肉瘤组织中FZD10的表达及其临床意义。方法:用S-P免疫组织化学染色法对69例骨肉瘤及35例骨软骨瘤中FZD10蛋白的表达进行检测,并对其与骨肉瘤临床病理及预后的关系进行统计学分析。结果:FZD10在骨肉瘤和骨软骨瘤组织中阳性表达率分别为89.9%和5.7%,P<0.01。FZD10蛋白表达与Enneking分期和Price分级呈正相关,与WHO分型和预后相关。结论:骨肉瘤FZD10蛋白的表达与肿瘤恶性程度密切相关,对骨肉瘤诊断和预后评估具有重要价值。Objective： To investigate the expression of FZD10 in osteosarcoma and their clinical significance.Methods：The expression of FZD10 protein was detected by the SP immunohistochemical method in 69 cases of osteosarcoma and 35 cases of osteochondroma.It＇s relationship to osteosarcoma clinical pathology and prognosis was analyzed statistically.Results： The positive rates of FZD10 were 89.9% and 5.7% in osteosarcoma and osteochondroma,respectively（P﹤0.01）.The expression of FZD10 was correlated to Enneking grade,Price grade,WHO classification and prognosis.Conclusion：The expression of FZD10 protein is closely correlated to malignant degree.It may serve as a valuable marker for diagnosis and an indicator to predict the prognosis of osteosarcoma.

关 键 词：骨肉瘤 FZD10 免疫组织化学 

分 类 号：R738[医药卫生—肿瘤]