中度海拔地区偏头痛患者血浆及脑脊液内皮素含量变化的研究  

Changes in plasma and cerebrospinal fluid endothelin1 levels in patients with migraine at moderate altitude

作　　者：韩影[1] 胡全忠[1] 郭晋晖[1] 侯倩[1] 宋文娟[1] 王莉[1] 李纯杰[1] 谢蓉星[1] 

机构地区：[1]青海省人民医院,青海西宁810007

出　　处：《中国危重病急救医学》1999年第10期607-608,共2页Chinese Critical Care Medicine

摘　　要：目的：探讨内皮素（ＥＴ）在中度海拔地区偏头痛发病中的作用。方法：对１００ 例中度海拔地区偏头痛患者血浆和脑脊液ＥＴ １ 含量的变化进行动态观察。结果：偏头痛患者（先兆型及无先兆型）发作期血浆及脑脊液的ＥＴ １ 含量均明显高于对照组（Ｐ均＜ ０．０５）；先兆型发作期ＥＴ １ 升高更明显（Ｐ＜ ０．０５）；发作后随时间推移、头痛缓解则血浆及脑脊液的ＥＴ １ 含量逐渐下降，头痛完全缓解后与对照组无明显区别（Ｐ 均＞０．０５）。结论：ＥＴ １Objective:To study the potential role of endothelin1(ET1)in the pathogenesis of migraine.Methods:Both plasma and cerebrospinal fluid (CSF) ET1 levels were measured in 100 patients with migraine at moderate altitude.Results:Plasma and CSF ET1 levels were significantly higher in patients during stage of attack than that in controls (both P <0 05),especially in those with premonitory type ( P <0 05).Plasma and CSF ET1 levels were gradually decreased in patients during remission stage,and they had no marked difference from controls after complete remission (both P >0 05).Conclusions:ET1 serving as a vasoconstrictor or neurohormone may play a role in the development of migraine at moderate altitude.

关 键 词：偏头痛 内皮素 血浆 脑脊液 

分 类 号：R747.2[医药卫生—神经病学与精神病学]