危重型脑出血双管引流疗效与局部自由基水平研究  

The relationship between local free radical release and clinical effectiveness of dual tube drainage in patients with severe intracerebral hemorrhage

作　　者：薛占苍[1] 张秀明[1] 安永辉[1] 黄振辉[1] 赵会颖[1] 刘培茹[1] 

机构地区：[1]河北省石家庄市第一医院,河北石家庄050011

出　　处：《中国危重病急救医学》1999年第10期630-632,共3页Chinese Critical Care Medicine

基　　金：河北省石家庄市科委指导性课题

摘　　要：目的：探讨危重型脑出血预后与局部自由基浓度的方法：对危重型脑出血行ＣＴ 引导下血肿抽吸引流并侧脑室引流，设计对照组单管血肿抽吸引流，同时分别测定血清、血肿及脑脊液内丙二醛（ＭＤＡ）及超氧化物歧化酶（ＳＯＤ）总活力。结果：血肿及脑脊液内局部ＭＤＡ 及ＳＯＤ水平均明显高于血清（Ｐ均＜ ０．０１）；双管引流术的临床疗效明显优于单管引流（Ｐ＜ ０．０１），但ＳＯＤ及ＭＤＡ 水平无差异（Ｐ均＞ ０．０５）。结论：脑损伤局部高自由基水平是病情严重程度的指标之一；双管引流法能明显缩短患者清醒时间。Objective:To investigate the relationship between the prognosis and concentrations of local free radicals in severe intracerebral hemorrhage.Methods:Under the guidance of CT,dual tube drainage of both hematoma and lateral ventricle was performed in patients with severe intracerebral hemorrhage.Meanwhile,single tube drainage of hematoma in patients served as controls.Malondialdehyde (MDA) and superoxide dismutase (SOD) were determined in serum,hematoma and cerebrospinal fluid.Results:It showed that the levels of MDA and SOD in local hematoma and cerebrospinal fluid were obviously higher than that in serum (all P <0 01).Dual tube drainage showed a better clinical results compared with single tube drainage.However,there was no significant difference in MDA and SOD levels between two groups(both P >0 05).Conclusions:The level of radicals at the site of brain damage might be one of indexes of degree of severity of the lesion.Dual tube drainage can significantly shorten the duration of unconsciousness of the patient.

关 键 词：脑出血 危重型 血肿抽吸术 侧脑室引流术 自由基 

分 类 号：R743.34[医药卫生—神经病学与精神病学]