亚硝酸钠和N-甲基苄胺的遗传毒性研究  

THE STUDY ON GENOTOXICITY OF SODIUM NITRITE AND N METHYLBENZYLAMINE

作　　者：洪振丰[1] 王郑选[1] 高碧珍[1] 许碧玉[1] 陈玲[1] 

机构地区：[1]福建中医学院生物学教研室,福州350003

出　　处：《癌变．畸变．突变》1999年第5期227-229,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：作者研究观察了亚硝酸钠和 Ｎ－ 甲基苄胺的遗传毒性作用。结果表明，亚硝酸钠和 Ｎ－ 甲基苄胺不产生急性遗传毒性（ Ｐ＞ ０ ．５） ，但具有中长期遗传毒性。长期接触可诱发大鼠胃窦及食道上皮的增生性病变，使胸腺指数降低，骨髓细胞 Ｍ Ｎ‰升高。The genotoxicity of sodium nitrite and N methylbenzylamine were detected. The results showed that sodium nitrite and N methybenzylamine did not induce acute genotoxicity(P>0.5),but had a middle and long term genotoxicity. Exposed for long term, the gastric antrum and exophagus in the rats showed different levels hyperplastic change; and the per mil rate of micronuclei of marrow cells increased; the thymus gland indexes lowered.

关 键 词：亚硝酸钠 N-甲基苄胺 遗传毒性 

分 类 号：R994.3[医药卫生—毒理学]