血管内皮生长因子和D114-Notch信号通路在肿瘤血管发生中的作用  

Roles of VEGF and Dil4-Notch signaling pathways in tumor angiogenesis

作　　者：冀俊琴[1] 周建华[1] 

机构地区：[1]哈尔滨医科大学附属第三医院内二科,150040

出　　处：《国际肿瘤学杂志》2011年第5期323-326,共4页Journal of International Oncology

基　　金：黑龙江省科学技术计划项目（GB06C40202）;黑龙江省卫生厅科研课题（2007-407）作者单位

摘　　要：抗肿瘤血管发生是一种全新的抗肿瘤治疗策略，目前研究最多的是寻找有效抗血管内皮生长因子（VEGF）信号通路的药物。然而VEGF抑制剂并不是对所有肿瘤有效，因此，有必要进一步探索血管发生的其他信号通路。目前，DH4-Nmch信号通路被认为是抗肿瘤血管发生的新靶点，而且VEGF和DH4-N0tch信号通路在多方面相互作用，在调控血管发生过程中发挥重要作用，对这两条通路的探索和研究，将会使治疗肿瘤的手段更为丰富。Anti-angiogenesis therapies have emerged as new treatment strategies for several types of tumors. To date, the most studied programs are to find out effective medicines to block the vascular endothelial growth factor （VEGF） signaling pathway. However, VEGF inhibitors are not effective to all kinds of tumors. Thus there is a need to explore other angiogenesis signaling pathways. Recently, the Dll4-Noteh pathway was identified as a new target in tumor angiogenesis. Moreover, an important feature in angiogenesis is the manifold ways in which the VEGF and Dll4-Notch pathways interact each other, which play critical roles in tumor angio- genesis. Therefore, the further exploration of these two pathways will provide more therapies for clinic to treat tumors.

关 键 词：肿瘤 受体 血管内皮生长因子 信号转导 

分 类 号：R730.2[医药卫生—肿瘤]