慢性萎缩性胃炎癌前病变患者报告临床结局评价量表的编制及信度、效度分析  

Development and Reliability & Validity Analysis of Patient Reported Outcome Scale for Precancerous Lesion of Atrophic Gastritis

作　　者：刘力[1] 常玉双[2] 沈舒文[1] 宇文亚[3] 惠建萍[1] 黄毓娟[1] 

机构地区：[1]陕西中医学院附属医院消化科,陕西省咸阳市世纪大道712046 [2]北京市昌平区中医医院 [3]中国中医科学院中医临床基础医学研究所

出　　处：《中医杂志》2011年第10期834-836,共3页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30873266)

摘　　要：目的编制慢性萎缩性胃炎癌前病变(PLGC)患者报告的临床结局(PRO)评价量表(PLGC-PRO量表),并对其信度及效度进行评价。方法通过文献查询、Delphi法、预调查等方法构建条目池,筛选优化条目,形成初步量表,在陕西地区进行量表测试,并对204份有效问卷进行信度、效度分析。信度分析主要采用测量内在一致信度的克朗巴赫α系数法、折半系数法;效度分析主要采用t检验考察其区分效度,采用探索性因子分析和证实性因子分析评价其结构效度。结果初步形成具有3个领域、30个条目的PLGC-PRO量表。该量表总克朗巴赫α系数为0.892,分半信度系数为0.715。量表各条目都达到了t检验法的保留标准(P<0.05);量表中30个条目经因子分析选出5个因子,累计方差贡献率为52.372%;量表的拟合优度指数(GFI)为0.954,生理领域、心理领域、社会环境领域的GFI分别为0.962、0.905和0.903。结论初步表明PLGC-PRO量表具有较好的信度、效度,可尝试用于PLGC患者的临床疗效评价。Objective To develop a precancerous lesion of atrophic gastritis patient reported outcome （PRO） scale （PLAG-PRO） and analyze its reliability and validity. Methods The scale was developed by establishing item pool through literature retrieval,Delphi method and pre-investigation,and selecting and optimizing items. Preliminary investigation was conducted in Shaanxi province,and the data of 204 valid respondents was used to assess the reliability and validity. The reliability was measured by internal consistency Cronbach＇s α coefficient and split-half coefficient. The discriminate validity and constructive validity were assessed by T test and exploratory factor analysis and confirmatory factor analysis respectively. Results The PLAG-PRO scale with 3 field and 30-item in it was developed. Its Cronbach＇s α coefficient was 0.892,split-half coefficient 0.715,and all items reached the reservation standard of T test （P0.05）. Five factors were selected from the 30 ones by factor analysis,which contributed to 52.372% of total variance. Goodness of fit index （GFI） of the scale was 0.954 and that of the physiological field,psychological field,and social field was 0.962,0.905,and 0.903 respectively. Conclusion The result shows that the scale has good reliability and validity. It can be applied for therapeutic evaluation of PLAG.

关 键 词：慢性萎缩性胃炎癌前病变 患者报告临床结局 量表编制 信度 效度 

分 类 号：R573.3[医药卫生—消化系统]