抗瘤增效方对非小细胞肺癌化疗患者的近期疗效及其对免疫功能的影响  

Short-term Effect of Kangliu Zengxiao Recipe and Its Influence on Immune Function of the Patients with Non-Small Cell Lung Cancer Treated by Chemotherapy

作　　者：邓海滨[1] 徐振晔[1] 王中奇[1] 蔡霄月[1] 吴继[1] 赵晓珍[1] 王立芳[1] 白冰[1] 苏婉[1] 

机构地区：[1]上海中医药大学附属龙华医院肿瘤科

出　　处：《中医杂志》2011年第10期848-851,874,共5页Journal of Traditional Chinese Medicine

基　　金：上海市级医院中医药验方临床评价项目(SHDC12008402);上海市浦东新区科技发展基金创新资金资助项目(PKJ2008-Y32)

摘　　要：目的观察抗瘤增效方对非小细胞肺癌(NSCLC)化疗患者的近期疗效及其对免疫功能的影响。方法采用随机对照前瞻性研究,将76例精气两亏型NSCLC住院患者分为治疗组、对照组各38例。两组患者化疗均采用诺维本+顺铂方案,治疗组加服抗瘤增效方(150ml/次,每日2次)。4周为1个疗程,连用2个疗程后观察两组瘤体稳定率、中医证候及卡氏评分的改善及免疫功能的变化。结果治疗后治疗组瘤体稳定率89.47%,显著高于对照组的71.05%(P<0.05)。治疗组中医证候改善的总有效率(71.05%)与对照组(36.84%)比较,差异有统计学意义(P<0.01)。治疗组和对照组卡氏评分总有效率分别为92.11%、57.89%,差异有统计学意义(P<0.01)。治疗组治疗后免疫指标CD3+、CD4+、CD4+/CD8+比值、自然杀伤细胞(NK细胞)活性、白介素-2(IL-2)均有不同程度提高,可溶性白介素-2受体(sIL-2R)明显下降,治疗前后自身对照差异有统计学意义(P<0.05)。两组治疗后比较NK、CD4+/CD8+比值升高及sIL-2R降低差异有统计学意义(P<0.05)。结论抗瘤增效方能提高NSCLC化疗患者的近期疗效,明显改善精气两亏型NSCLC患者临床证候,并能提高患者机体免疫能力。Objective To observe the short-term effect of Kangliu Zengxiao Recipe （Herbal decoction for resisting cancers） and its influence on immune function of the patients with non-small cell lung cancer （NSCLC） treated by chemotherapy. Methods In this prospective,randomized,and controlled trial,76 NSCLC patients were assigned to a treatment group and a control group,38 cases in each. Both groups were given navebine （NVB） and cisplatin dichloro diamine platinum （cis-DDP）. Additionally,the treatment group was administered Kangliu Zengxiao Recipe 150ml,twice a day for oral taking. Four weeks as one course,two courses in succession. Improvement of tumor size stable rate,Score of TCM syndrome,Karnofsky score,and immune function of both groups observed. Results After treatment,the tumor size stable rate of the treatment group was 89.47%,significantly higher than 71.05% of the control group （P0.05）. The total effective rate of the improvement of TCM syndrome was 71.05%,significantly different from 36.84% of the control group （P0.01）. The total effective rate of Karnofsky score of both groups was 92.11% and 57.89% respectively in a significant difference （P0.01）. The level of CD3＋,CD4＋,CD4＋/CD8＋,activity of natural killer （NK） cells and interleukin 2 （IL-2） of the treatment group was increased to different degrees,while the soluble interleukin 2 receptor （sIL-2R） was significantly decreased. The self-control of the treatment group showed a statistical difference before and after treatment （P0.05）. There was statistical difference in the increase of NK cells and CD4＋/CD8＋ and the decrease of sIL-2R in the comparison of the two groups before and after treatment （P0.05）. Conclusion Kangliu Zengxiao Recipe is effective in improving the shor-term therapeutic effect of chemotherapy for the NSCLC patients,significantly relieving the clinical symptoms of essence and qi deficiency syndrome,and enhancing the immune function of the patients.

关 键 词：非小细胞肺癌 精气两亏 抗瘤增效方 近期疗效 免疫功能 

分 类 号：R734.2[医药卫生—肿瘤]