代谢组学技术在女性更年期惊恐障碍防治机制中的应用思考  

Thinking on application of metabonomics technologies in mechanism research on treatment of menopausal panic disorder

作　　者：陈贵珍 许云祥[2] 王小云 

机构地区：[1]广州中医药大学第二附属医院,广州510120 [2]广州中医药大学针灸推拿学院,广州510405

出　　处：《中华中医药杂志》2011年第5期1067-1071,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广东省自然科学基金项目(No.8151040701000033);Special Grade of the Financial Support from China Postdoctoral Science Foundation(No.201003344);Postdoctoral Science Foundation from Guangzhou University of Chinese Medicine(No.B3YH1005)~~

摘　　要：女性更年期惊恐障碍是发生在更年期的典型心身疾病之一,严重威胁中老年人的身心健康,寻找一种更为安全,有效的方法防治本病是现代医学所面临的问题之一。在回顾中西医对女性更年期惊恐障碍病因病机的基础上,进一步分析了补肾益髓埋线法在防治女性更年期惊恐障碍的优势和取穴组方原则、代谢组学技术在穴位埋线防治更年期惊恐障碍机制研究中的应用思路;指出补肾益髓埋线法是治疗女性更年期惊恐障碍的安全、有效的方法之一;利用代谢组学技术,穴位埋线防治女性更年期惊恐障碍有望在发病机制、优化穴位组合及治病机制研究方面取得突破性的进展。Menopausal panic disorder is a kind of the typical psychosomatic diseases during climacteric period,which may affect their physical and mental health.Looking for a convenient,effective,and safe method without toxic-side effects to control the disease is a modern medical problem.Based on reviewing the knowledge of both TCM and western medicine for the etiology and pathogenesis of menopausal panic disorder;further analyzing the advantage and selecting prescription principles on the tonifying kidney and benefiting marrow by acupoint catgut-embedding methods for the treatment of menopausal panic disorder,thinking on the application of metabonomics technologies in the mechanism research on the treatment of menopausal panic disorder were discussed.It＇s pointed out that this therapy is safe and effective to treat menopausal panic disorder.Breakthrough will be achieved from the research of the selection of the acupoint prescription and mechanism of acupoint catgut-embedding method for the treatment of menopausal panic disorder by utilizing the Metabonomics technologies.

关 键 词：女性更年期惊恐障碍 补肾益髓埋线法 代谢组学 

分 类 号：R749.7[医药卫生—神经病学与精神病学]