中医药抗胃癌转移研究进展  

Progress in anti-metastasis research of Traditional Chinese Medicine in Gastric Cancer

作　　者：王海永[1] 沈克平[1] 胡兵[1] 

机构地区：[1]上海中医药大学附属龙华医院肿瘤五科,上海200032

出　　处：《中华中医药学刊》2011年第5期1026-1028,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30873258);上海市浦东新区中医领军型人才资助项目(PWZ2008-20-104)

摘　　要：胃癌作为一种常见恶性肿瘤,其发病率及死亡率均居恶性肿瘤首位。而转移作为胃癌晚期的重要特点之一,是患者死亡的重要原因。胃癌转移是胃癌细胞通过血管、淋巴管播散到新的地方生长成实体瘤。临床研究表明中医药具有一定抗胃癌转移作用;实验研究表明中医药可能通过多种机制干预胃癌转移过程,包括基质金属蛋白酶机制、血管内皮生长因子机制、癌基因与抑癌基因机制、细胞粘附分子机制等。综合目前研究,进步综述中医药抗胃癌转移作用。The incidence rate and mortality rate of Gastric cancer is the highest of all malignant tumors. Metastases as an important feature of advanced gastric cancer are the major cause of death from gastric cancer. Gastric cancer metastasis may occur via the blood or the lymphatics or through both routes. Clinical studies showed that some Chinese herb can inhibit the metastasis of gastric cancer. Experimental studies demonstrated that anti - metastasis effects of Chinese herb involve multiple mechanisms, including matrix metalloproteinases, vascular endothelial growth factor,oncogenes and tumor suppressor genes, or cell adhesion molecules. This review summarizes the current progress in the research field of Chinese herb inhibit the metastasis of gastric cancer.

关 键 词：胃癌 转移 临床研究 实验研究 中医药 

分 类 号：R735.2[医药卫生—肿瘤]