膀胱癌术后行卡介苗联合干扰素膀胱灌注化疗的临床观察  

The clinical effect of intravesica linstillation chemotherapy of bacillus calmette guerin and interferon α after surgical treatment of bladder tumor

作　　者：赵莎平[1] 

机构地区：[1]成都大学附属医院,610081

出　　处：《浙江临床医学》2011年第5期513-515,共3页Zhejiang Clinical Medical Journal

摘　　要：目的 探讨膀胱癌术后行卡介苗联合干扰素膀胱灌注化疗的临床疗效和安全性.方法 将80例膀胱癌术后的患者随机分成两组,观察组和对照组各40例.观察组膀胱灌注化疗采用卡介苗联合干扰素α,对照组采用丝裂霉素-C.手术2周后开始行膀胱灌注化疗,1次/周,连续8次后改为1次/2周,连续8次后改为1次/月,连续用药2年.观察比较两组患者的不良反应,随访2年比较复发率和生存率,尿液中白细胞介素-2和肿瘤坏死因子水平.结果 两组患者不良反应发生率差异无统计学意义（P＞0.05）,但随访2年,观察组患者复发率和生存率分别为10.00%、95.00%,明显优于对照组的35.00%、77.50%,差异有统计学意义（P＜0.05）.观察组尿液中白细胞介素-2和肿瘤坏死因子水平均好于对照组（P＜0.05）.结论 膀胱癌术后行卡介苗联合干扰素膀胱灌注化疗安全有效,可以提高机体免疫力和生存率,减少复发,值得临床推广应用.Objective To explore the clinical effect and safety of intravesica linstillation chemotherapy of bacillus calmette guerin and interferon a after surgical treatment of bladder tumor. Methods 80 cases patients after surgical treatment of bladder tumor were randomly divided into the intervention group（40 cases） and control group（40 cases） ; The patients in intervention group were treated with bacillus calmette guerin and interferon a, the control group were treated with mitomycin - C; Bladder infusion chemotherapy after 2 weeks surgery, once a week for 8 weeks, once two weeks for 14 weeks and once a month, the treatment continued for 2 years. After following - up for2 years, the incidence of adverse reactions, recurrence rate and survival rates, levels of IL - 2 ,TNF in urine were observed and compared. Results Their incidence of adverse reactions were no difference （ P 〉 0. 05 ）, after following -up for 2 years, the recurrence rate and survival rates in the intervention group were respectively 10. 00%, 95.00% , they were better 35.00%, 77. 50% in the control group, there were significant differences （P 〈 0. 05 ）. Levels of IL -2 ,TNF in urine in the intervention group were better than the control group （P 〈 0. 05）. Conclusion Intravesica linstillation chemotherapy of bacillus calmette guerin and interferon α after surgical treatment of bladder tumor is more effective and safe, can improve immunity and survival rate, reduce recurrence, and hence is worthy of being recommended in clinical practice.

关 键 词：膀胱癌 膀胱灌注化疗 卡介苗 干扰素 丝裂霉素-C 

分 类 号：R737.14[医药卫生—肿瘤]