脏器炎性肌纤维母细胞肿瘤的诊断与鉴别诊断  

Diagnosis and Differential Diagnosis of Inflammatory Myofibroblastic Tumor of Viscera

作　　者：宋林勇[1] 黄晓赤[2] 简燚[3] 曾冬梅[3] 

机构地区：[1]都江堰市医疗中心病理科,四川611830 [2]成都市第六人民医院病理科 [3]成都军区总医院病理科

出　　处：《西南军医》2011年第3期395-397,共3页Journal of Military Surgeon in Southwest China

摘　　要：目的探讨脏器炎性肌纤维母细胞瘤(Inflammatory miofibroblastic tumor,IMT)的诊断和鉴别诊断。方法分析21例IMT的临床病理特征,病理组织学特点和免疫组化表型。所有病例行HE染色和免疫组化染色。结果脏器IMT主要有三种细胞:肌纤维母细胞,纤维母细胞和炎细胞,这些细胞构成了IMT的三种组织学亚型:(1)黏液-血管型;(2)梭形细胞密集型;(3)少细胞纤维瘢痕型。所有病例表达Vim、SMA和MSA,部分病例表达PCK和ALK。结论脏器IMT的病理组织学和免疫表型是诊断的重要依据,鉴别诊断包括腹腔黏液囊肿和肿瘤,钙化性纤维性肿瘤,孤立性纤维性肿瘤,伴淋巴组织浸润的平滑肌瘤、和胃肠间质瘤。Objective To discuss the diagnosis and differential diagnosis of inflammatory myofibroblastic tumor（IMT）of viscera.Methods An analysis was made to the clinical pathological features,the histopathological features and immunohistochemical phenotype of 21 cases with IMT;HE staining and immunohistochemical staining were made to all the samples.Result There were 3 kinds of cells in IMT of viscera： myofibroblast,fibroblast and inflammatory cells,which formed up 3 histological subtypes： myxoid-vascular pattern,companct spindle cell pattern and hypocellular-fibroscar pattern;the expressions of Vim,SMA and MSA were found in all the cases while those of PCK and ALK in some cases.Conclusions The histopathological study and immunophenotyping of IMT of viscera are the important evidence in its diagnosis,the differential diagnosis includes abdominal peritoneal mucocele,calcifyingfibroustumor,（CFT）,solitary fibrous tumor（SFT）,leiomyoma with lymphoidinfiltrates and gastrointestinal stromal tumors（GIST）.

关 键 词：炎性肌纤维母细胞瘤 免疫组织化学 

分 类 号：R735.4[医药卫生—肿瘤]