海马及相关神经递质对抑郁症发病机制的影响  

The Influence of Hippocampus and Neurotransmitters on the Pathological Mechanism of Depression

作　　者：王丹[1] 

机构地区：[1]西安文理学院生命科学系,陕西西安710065

出　　处：《西安文理学院学报（自然科学版）》2011年第2期9-13,共5页Journal of Xi’an University(Natural Science Edition)

基　　金：西安文理学院科研基金资助项目(kyc200812)

摘　　要：随着生活节奏的加快、工作竞争激烈等应激因素的加剧,抑郁症的发病率逐年升高.最近研究表明抑郁症是与控制心境相关的大脑不同区域神经可塑性改变的结果,这些变化主要表现在海马区域神经发生减少,锥体神经元萎缩,神经胶质细胞密度减低,海马体积减小等.研究抑郁症病理机制,对治疗抑郁症至关重要.就海马及相关神经递质对抑郁症发病机制的影响作一综述.With the intensification of fast tempo of life and competition in workplace,the incidence of depression is becoming higher every year.Recent research shows that depression results from the change of plasticity of nerves controlling the frame of mood in various areas of the brain.The change is manifested as the reduction of neurogenesis,the shrinking of cone neurone,the shrinking density of neuroglia cell in the area of the hippocampus and diminishing of hippocampus.The study of pathomechanism is of great significance for curing depression.This paper gives a literature review of the influence of the hippocampus and the neurotransmitters on pathomechanism of depression.

关 键 词：抑郁症 一氧化氮 脑源性神经营养因子 

分 类 号：R749.4[医药卫生—神经病学与精神病学]