镭射光钳拉伸下受疟原虫寄生红细胞的有限元分析  

Finite element analysis of malaria infected erythrocyte stretched by optical tweezers

作　　者：焦古月[1] 道明[2] 林水德[3] 张若京[1] 

机构地区：[1]同济大学,上海200092 [2]麻省理工学院,Cambridge,MA02139,USA [3]新加坡国立大学,S117576,Singapore

出　　处：《计算力学学报》2011年第B04期141-146,共6页Chinese Journal of Computational Mechanics

基　　金：国家自然科学基金(10772136,11072178);上海市重点学科建设项目(B302)资助

摘　　要：疟疾是由疟原虫引起的传染病,是人类的最大杀手之一。在四种可以感染人类血细胞的疟原虫中,恶性疟原虫最为致命。健康血红细胞具有很强的变形能力,但受到恶性疟原虫寄生后,宿主红细胞的变形能力下降,引起血管阻塞,从而对健康造成极大伤害。近年来,镭射光钳技术被用于测试受疟原虫寄生红细胞的变形能力。本文应用有限元方法对镭射光钳拉伸下血红细胞的力学行为进行了模拟,得到了细胞膜弹性模量在增殖周期不同阶段中的变化。与其他学者实验数据的对比表明,两者吻合较好,并对现有模型进行了优化。该模型可用于预测受疟原虫寄生血红细胞在不同增殖阶段不同受力环境下的变形,为微血管床阻塞的力学机制和治疗机制提供了可靠参考。Malaria is a severe disease transmitted by malaga parasites, causing millions of deaths each year. Among the four different species of the malaga parasites that infect humans, Plasmodium falciparum is the most deadly serious. Healthy erythrocytes are highly deformable. However, when the Plasmodium falciparum parasite invades into the erythrocyte, it causes the host cell to lose its deformability and results in capillary blockage. Optical tweezers have been used to measure the mechanical properties of malaga infected erythrocytes. Here, a fmite element model was developed to simulate the cell deformation induced by optical tweezers stretching, and to quantitatively evaluate the stiffening of cell membrane with the progression of parasite maturation. This model can be used to predict the deformation of malaga infected erythrocytes during different infectious stages under different loading conditions, and thus provide reference to the mechanical and therapeutic mechanism of capillary blockage.

关 键 词：细胞力学 疟疾 镭射光钳 有限元分析 红细胞 

分 类 号：O242[理学—计算数学]