凋亡抑制因子Livin和Survivin在大肠癌组织中的表达及预后判断价值  

Expression of Livin and Survivin in Colorectal Cancer Tissue and Its Prognosis Value

作　　者：任崇禧[1] 张志刚 

机构地区：[1]沧州中西医结合医院外四科,河北沧州061000 [2]沧州市人民医院病理科,河北沧州061000

出　　处：《临床误诊误治》2011年第5期7-10,共4页Clinical Misdiagnosis & Mistherapy

摘　　要：目的分析凋亡抑制因子Livin和Survivin在大肠癌组织中的表达及其判断预后的价值。方法选取我院2003年1月～12月手术切除并经病理证实、资料完整的61例大肠癌、17例癌旁组织及32例良性肿瘤标本的存档蜡块,应用免疫组化Elivision法检测Livin和Survivin的基因表达,分析两者与大肠癌患者生存率的关系。结果 Livin和Survivin在大肠癌组织中的阳性率明显高于癌旁组织和良性肿瘤(P<0.01,P<0.05);在复发或转移的大肠癌病例标本中Livin阳性表达率高于无复发或转移者(P<0.05)。Livin和Survivin在大肠癌组织中的表达不具有相关性(P>0.05)。Livin阳性者5年生存率低于Livin阴性者(P<0.05);Survivin阳性者5年生存率低于Survivin阴性者(P<0.05)。大肠癌患者生存率与Livin和Survivin的阳性表达呈负相关(P<0.05)。结论 Livin和Survivin均高表达于大肠癌组织中,可能对大肠癌的发生、发展有促进作用,有望作为肿瘤标记物用于判断大肠癌的预后;Livin与患者术后的复发、转移及预后关系更为密切。Objective To investigate the expression of Livin and Survivin gene and evaluate its prognosis value of colorectal cancer. Methods A total of 61 specimens of colorectal cancer tissues, 17 specimens of paraneoplastic tissues, and 32 specimens of benign neoplasm tissues diagnosed from January 2003 to December 2003 by postoperative pathology were selected. The expression of Livin and Survivin in the patients were examined by Elivision immunohistochemistry. The correlation between survival rate in colorectal cancer patients and the expression of Livin and Survivin were analyzed. Results The positive expressions of Livin and Survivin gene in colorectal cancer tissues were significantly higher than that in paraneoplastic tissues and benign neoplasm tissues, and the differences were significant （P 〈 0. 05, P 〈 0. 01 ） ; The expression of Livin was highly expressed in colnrectal cancer patients with recurrence and metastasis than those without recurrence and metastasis （ P 〈 0.05 ）. No relationship was found between the expression of Livin and Survivin in colorectal cancer tissues （P 〉 0. 05 ）. The 5 years total survival rate in patients with Livin positive tissues was lower than that in patients with negative tissues （ P 〈 0.05 ） , and it in patients with survivin positive tissues was lower than that in patients with negative tissues （ P 〈 0.05 ）. The prognosis of colorectal cancer patients was negatively related to the expression of Survivin and Livln （P 〈 0. 05）. Conclusion Both Livin and Survivin are highly expressed in colorecta｜ cancer tissues, and may contribute to the cause and development of the disease, and may be used as tumor makers to predict the prognosis of the patients. Livin was more closely related to recurrence, metastasis and prognosis of the patients.

关 键 词：肠肿瘤 LIVIN SURVIVIN 免疫组织化学 

分 类 号：R735.34[医药卫生—肿瘤]