S100A9在急性髓系白血病中的表达及意义  

Expression of S100A9 and Its Significance in Acute Myeloid Leukemia

作　　者：曹晓丽[1] 侯春燕[1] 林应标[1] 郭满荣[1] 颜复生[1] 何准发[1] 

机构地区：[1]湖南省郴州市第一人民医院,湖南郴州423000

出　　处：《实用预防医学》2011年第4期615-617,共3页Practical Preventive Medicine

摘　　要：目的探讨S100A9在急性髓系白血病中的表达及意义。方法采用逆转录聚合酶链反应(RT-PCR)技术和免疫印迹(Western blotting)方法,从62例急性髓系白血病和12例非恶性血液病骨髓中,检测S100A9 mRNA及蛋白表达情况,分析S100A9在急性髓系白血病中和非恶性血液病表达差异及临床关系。结果急性髓系白血病组S100A9的mRNA及蛋白表达均低于非恶性血液病组(P<0.05),并且S100A9在治愈的AML中表达升高(P<0.05)。结论 S100A9在急性髓系白血病中表达降低,S100A9表达水平可能是急性髓系白血病进展判断的重要标志物。Objective To explore the expression and clinical value of S100A9 in acute myeloid leukemia. Methods RT-PCR and Western blotting were performed to detect the mRNA and protein of S100A9 in acute myeloid leukemia group（n=62） and non-hematologic malignancies group（n=12）. Results The mRNA and protein of S100A9 in acute myeloid leukemia group were both lower than those of non-hematologic malignancies group（P0.05）,and the expression levels of S100A9 were up-regulated in the cured AML（P0.05）. Conclusions S100A9 shows lower expression in acute myeloid leukemia compared with non-hematologic malignancies,and the expression levels of S100A9 might be a useful prognostic marker for judging disease progression of AML.

关 键 词：S100A9 急性髓系白血病 表达 

分 类 号：R733.7[医药卫生—肿瘤]