大肠癌术前放免治疗及化疗与肿瘤坏死的相关性研究  

Correlativity of preoperative therapy with necrosis of tumor tissue in colorectal carcinoma

作　　者：卢献平[1] 董功航[1] 李宝金[1] 陈声乐[1] 吕斌[1] 蒋宁一[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院,广州510120

出　　处：《癌症》1999年第5期583-585,共3页Chinese Journal of Cancer

摘　　要：目的：研究大肠癌术前放射免疫治疗及化疗（ 或导向化疗） 对大肠癌组织及细胞的影响。方法：６３ 例大肠腺癌患者随机分成五组。Ａ 组１６ 例，术前肿瘤局部注射１３１Ｉ抗ＣＥＡ 单抗；Ｂ 组１０ 例，术前肿瘤局部注射１３１Ｉ；Ｃ 组７例，术前静脉注射丝裂霉素Ｃ；Ｄ 组１３ 例，术前静脉注射抗ＣＥＡ 单克隆抗体丝裂霉素Ｃ 交连物；Ｅ 组１７ 例术前不注射上述各种药物。其后对所有患者行手术并切取标本进行病理组织学观察。结果：肿瘤组织病理退变（ 坏死） 程度：Ａ 组肿瘤组织病理退变程度１ 级２ 例（１２－５％ ） ，２ 级１０ 例（６２－５ ％ ） ，３ 级４ 例（２５％ ） ；Ｂ 组分别为１ 级６ 例（６０ ％ ） ，２ 级４例（４０ ％ ） ；Ｃ 组分别为１ 级２ 例（２８－６ ％ ） ，２ 级５ 例（７１－４％ ） ；Ｄ 组１ 级２ 例（１５－３ ％ ） ，２ 级７ 例（５３－９ ％ ） ，３ 例４ 例（３０－８％ ） ；Ｅ 组病理退变程度１７ 例（１００－０ ％ ） 均为１ 级。结论：１－ 大肠癌术前放射免疫治疗、化疗（ 或导向化疗） 及局部注射放射性核素１３１Ｉ 均能导致肿瘤细胞退行性变。２－ 肿瘤术前治疗对大肠癌手术切除有利。Objective:To study the influence of preoperative radioimmunotherapy and chemotherapy (or targeting chemotherapy) on neoplsatic cells of colorectal carcinoma (CRC). Methods:Sixty three patients were divided into five groups.Group A (16 cases) had been injected with anti CEA monoclonal antibody,C50 131I conjugates with mitomycin C, at tumor location for preoperative radioimmunotherapy.Group B (10 cases) had been injected with 131I at tumor location before operation.Group C (7 cases) had received preoperative i.v. mitomycin for chemotherapy.Group D (13 cases) had recived preoperative i.v. targeting chemotherapy with CEA mitomycin. Group E (17 patients) had not received any preoperative anti tumor medication. The tumors of all patients were resected.The resected specimens were assessed by histologic examination.Results:In group A,there were 2 cases in 1st grade,10 cases in 2nd grade and 4 cases in 3rd grade necrosis of tumor tissue.In group B,6 cases in 1st grade, 4 cases in 2nd grade and no cases in 3rd grade necrosis.In group C,2 cases in 1st grade,5 cases in 2nd grade necrosis.In group D, 2 in 1st grade,7 in 2nd and 4 in 3rd grade necrosis.But in group E,all resected tumor tissues of 17 patients were in 1st grade necrosis.Conclusion:①Preoperative radioimmunotherapy,chemotherapy (or tageting chemotherapy) and preoperative injection of radioisotope 131I could cause necrosis of tumor tissue.②It was considered to be useful using preoperative treatment to colorectal carcinoma.

关 键 词：大肠肿瘤 肿瘤坏死 手术前 放射免疫疗法 

分 类 号：R735.340.5[医药卫生—肿瘤]