肝细胞癌DNA倍体类型与放射治疗预后的关系  

RELATIONSHIP BETWEEN DNA PLOIDY AND PROGNOSIS IN HEPATOCELLULAR CARCINOMA AFTER RADIATION THERAPY

作　　者：黄挺[1] 于尔辛[1] 曹世龙[1] 

机构地区：[1]上海医科大学肿瘤医院,上海200032

出　　处：《中国癌症杂志》1999年第3期203-205,共3页China Oncology

摘　　要：目的　研究肝细胞癌ＤＮＡ 倍体类型与放射治疗预后的关系。　方法　４１ 例肝癌患者，其中男性３７例，女性４ 例，用肝瘤穿刺吸取标本并进行ＤＮＡ 倍体类型分析。　结果　①二倍体肝癌１７ 例（占４１５ ％） ，异倍体肝癌２４ 例（ 占５８５ ％ ） 。②放射治疗过程中，异倍体肝癌恶化者明显较二倍体肝癌为多（Ｐ＜ ００１） ，其预后亦较二倍体肝癌差（ Ｐ＜ ００１）。③不同倍体类型的表现与肿块大小、肿瘤大体类型、ＡＦＰ水平及癌细胞的分化程度并无显著关系。　结论　肝细胞癌的倍体类型有独立的生物学行为，对估计患者预后有积极意义。To study the relationship between DNA ploidy and prognosis in hepatocellular carcinoma.METHODS 41 Patients were entered into this study,37 of which were male and 4 were female. Specimens obtained by percutaneous liver puncture were analysed by flow cytometry.RESULTS ①17 patients (41.5%) were diploid and the others (58.5%) were aneuploid.②In the course of radiation therapy,patients with aneuploid type were more frequently correlated with progressive disease ( P <0 01) and with poorer prognosis than those with diploid type ( P <0 01) ③No significant difference in DNA ploidy was seen with regard to tumor size,gross type,AFP levels,and histopathologic grade ( P>0 05)。CONCLUSIONS DNA ploidy has its own biological behavior,which has great significance in evaluating the prognosis of patients.

关 键 词：DNA倍体 肝肿瘤 放射疗法 预后 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤] R730.55[医药卫生—临床医学]