醛氢叶酸联合氟尿嘧啶系列方案治疗93例晚期结直肠癌  

TREATMENT OF 93 CASES WITH ADVANCED COLORECTAL CARCINOMA USING A SERIES OF LEUCOVORIN PLUS 5 FLUOROURACIL REGIMENS

作　　者：潘良熹[1] 郑秀立[1] 黄富麟[1] 吴罕莉[1] 宋依霖[1] 祝浩强[1] 冯继峰[1] 陈嘉[1] 

机构地区：[1]江苏省肿瘤医院内科,南京210009

出　　处：《中国癌症杂志》1999年第3期221-223,共3页China Oncology

摘　　要：目的　研究醛氢叶酸（ＬＶ）联合氟尿嘧啶（５ＦＵ） 系列方案治疗晚期结直肠癌近期疗效和毒性。　方法　９３ 例分别接受下列化疗①Ａ（ＬＦ） 组：５ＦＵ（５００ ｍｇ／ｍ２·ｄ－ １） 加ＬＶ（２０ ｍｇ／ｍ２·ｄ－ １） 静脉连续５ｄ，３ 周重复；②Ｂ（ＬＦＰ） 组：将顺铂（ＰＤＤ４０ ｍｇ／ｄ 静脉连续３ｄ） 加入Ａ 组中；③Ｃ（ＬＦＨ） 组：将羟基喜树碱（ＨＣＰＴ６ ～８ ｍｇ／ｍ２·ｄ－ １ 静脉连续５ ～１０ｄ） 加入Ａ 组中。每例２ 疗程后作疗效、不良反应评价。　结果　有效率分别为Ａ组１２５ ％（５／４０）、Ｂ组２２２％ （６／２７） 和Ｃ组３４６ ％（９／２６），Ｃ组显著高于Ａ组（ Ｐ＜ ００５） ；胃肠道反应和骨髓抑制Ｂ 组较Ａ 组增加，Ｃ组较Ａ 组无明显增加。　结论　ＬＦＰ方案价值有待进一步研究，临床上可有选择地应用。ＬＦＨ 方案是治疗晚期结直肠癌有希望的方案。To study initial responses and toxicities of a series of leucovorin(LV) plus fluorouracil(5 FU) regimens in the treatment of advanced colorectal carcinoma.METHODS Ninety three patients respectively received chemotherapy as follows:①group(LF) A 5 FU(500?mg/m 2·d -1 ) plus LV(20?mg/m 2·d -1 ) was administered iv for 5 d every 3?wk;②group(LFP)B cisplatin(PDD,40?mg/d administered iv for 3d) was added to 5 FU/LV in group A above;③group(LFH)C hydroxyl camptothecin (HCPT,6-8?mg/m 2·d -1 administered iv for 5-10 d) was added to 5 FU/LV in group A above.Each case was assessed after 2 courses of treatment.RESULTS The objective response rates were 12.5%(5/40) in group A,22.2%(6/27) in group B and 34.6%(9/26) in group C.The response rate in group C was more pronounced than that in group A with statistical significance ( P <0 05),but adverse reactions were not markedly increased.CONCLUSIONS LFP regimen value merits further clinical test and is used selectively.LFH regimen seems to be a promising regimen in the treatment of advanced colorectal carcinoma.

关 键 词：结肠肿瘤 直肠肿瘤 醛氢叶酸 氟尿嘧啶 

分 类 号：R735.305[医药卫生—肿瘤] R730.53[医药卫生—临床医学]