J-911对实验性肝损伤的保护作用  

THE PROTECTIVE EFFECTS OF J-911 ON EXPERIMENTAL LIVER INJURY

作　　者：曹伟[1] 王菊英[1] 马剑峰[1] 袁玮[1] 

机构地区：[1]山东医科大学基础医学院药理教研室,济南250012

出　　处：《中国海洋药物》1999年第3期26-29,共4页Chinese Journal of Marine Drugs

摘　　要：通过建立小鼠急性肝损伤及大鼠慢性肝损伤模型，观察并研究海洋药物Ｊ－ ９１１对小鼠急性肝损伤及大鼠慢性肝损伤的保护作用。结果表明，Ｊ－９１１能明显降低Ｄ－半乳糖胺引起急性肝损伤小鼠的血清ＡＬＴ升高和四氯化碳引起的急性肝损伤小鼠的血清ＡＬＴ、ＡＳＴ的升高，明显减轻模型肝组织病理损伤。Ｊ－９１１还可显著降低肝纤维化大鼠血清ＡＬＴ、ＡＳＴ水平及肝组织羟脯氨酸含量，并明显减轻肝组织病理损伤。说明Ｊ－９１１对实验性肝损伤具有保护作用。The projective effects of J - 911 on the acute liver injury in mice and the chronic liver in jury in rats were observed and studied by establishing animal models. The results showed that J - 911 sig nificantly decreased the elevation of serum ALT induced by Galn and the elevation of serum ALT. J - 911 markedly decreased the elevation of serum AST. ALT and hydroxyproline in liver tissue of hepatic fibrosis rats induced by ccl_4, the liver tissue injuries of hepatic fibrosis rats were also ameliorated. The results sug gest that J - 911 may have protective effects on experimental liver injury.

关 键 词：J-911 肝损伤 肝纤维化 动物实验 

分 类 号：R575.05[医药卫生—消化系统] R931.77[医药卫生—内科学]