黛力新治疗偏头痛伴焦虑或抑郁患者的临床观察  

Deanxit treatment of migraine in patients with anxiety or depression,clinical observation

作　　者：方玲[1] 张伟国[1] 雷建明[1] 杜伟杰[1] 

机构地区：[1]茂名市人民医院脑内三科,广东茂名525000

出　　处：《医学信息（中旬刊）》2011年第5期2081-2082,共2页Medical Information Operations Sciences Fascicule

摘　　要：目的:探索治疗偏头痛伴有焦虑和/或抑郁患者的有效方法,以及研究联合应用抗焦虑/抑郁药物的疗效。方法:将80例偏头痛伴有焦虑和/或抑郁的患者随机分为2组。治疗组40例,用黛力新+非甾体抗炎药(主要成分为对乙酰氨基酚)治疗;对照组40例,单用非甾体抗炎药治疗,并进行随机单盲对照研究。同时用汉密尔顿焦虑量表评分(HAMA)和汉密尔顿抑郁量表评分(HAMD),经抗焦虑和/或抗抑郁治疗前及治疗后(第4、8周)进行评估。结果:治疗组患者头痛发作次数显著减少或消失,头痛程度显著减轻或消失,头痛发作持续时间缩短,同时能显著减少(HAMA)(第4、8周均P<0.01)和(HAMD)(第4、8周均P<0.01)。结论:对偏头痛伴有焦虑和/或抑郁的患者,除对症治疗外,联用黛力新可提高疗效。Objective：To explore the treatment of migraine associated with anxiety and/or effective way to depression and anxiety combined research/depression, the effect of drugs. Methods：80 patients with migraine associated with anxiety and/or depression were randomly divided into 2 groups. 40 patients treated with Deanxit ＋ non- steroidal antiinflammatory drugs （mainly paracetamol） treatment ,40 patients in control group, single -use non- steroidal anti -inflammatory drug treatment, and randomized single blind controlled study. At the same time with the Hamilton anxiety scale score （HAMA） and Hamilton depression scale （HAMD）, by anxiety and/or antidepressant therapy before and after treatment （ the first 4,8 weeks） for evaluation. Results ：The treatment group were headache, seizure frequency was significandy decreased or disappeared, headache level was significantly reduced or disappeared, headache duration, also significantly reduced （HAMA） （4 weeks,8 weeks, all P 〈 0.01 ） and （HAMD） （4 weeks,8 weeks, all P 〈 0.01 ）. Conclusion：Migraine associated with anxiety and/or depressed patients, in addition to symptomatic treat- ment,eombined with Deanxit may improve the outcome.

关 键 词：黛力新 偏头痛 焦虑 抑郁 

分 类 号：R749[医药卫生—神经病学与精神病学]