脑出血和脑梗死患者的血栓调节蛋白和蛋白C浓度比较研究  

Study on concentration of thrombomodulin and protein C in patiens with cerebral infarction and hemorrhage

作　　者：张佩利[1] 刘建仁[1] 黄鉴政[1] 

机构地区：[1]浙江医科大学附属第二医院神经内科,310009

出　　处：《中风与神经疾病杂志》1999年第5期268-269,共2页Journal of Apoplexy and Nervous Diseases

摘　　要：目的　探讨脑血管病患者血浆血栓调节蛋白（ＴＭ ）和蛋白Ｃ（ＰＣ）的水平。方法　应用ＥＬＩＳＡ 法对４５ 例脑梗死患者、１６ 例脑出血患者和对照组２４ 例健康体检者血浆ＴＭ 和ＰＣ进行了检测。结果　脑梗死组ＴＭ 水平显著高于对照组（Ｐ＜ ０．００１） ， 而脑出血组的ＰＣ水平显著高于对照组（Ｐ ＜０．０１）。结论　高水平的ＴＭ 提示脑梗死有较严重的血管内皮的损伤，高水平的ＰＣ提示脑出血患者存在ＰＣ抗凝系统的异常。Objective To meassure the thrombomodulin and protein C levels in patiens with stroke. Mathods The thrombomodulin and protein C levels of 45 cerebral infarction,16 cerebral hemorrhage and 24 controls were mearsured by means of ELISA. Results TM was higher in cerebral infarction than in controls (P<0.001);PC was higher in cerebral hemorrhage than in controls(P<0.01). Conclusion Cerebral infarction has severe endothelial damage,and PC anti coagulation is abnomal in cerebral hemorrhage.

关 键 词：脑出血 脑梗死 血栓调节蛋白 蛋白C ELISA 

分 类 号：R743.340.2[医药卫生—神经病学与精神病学] R743.330.2[医药卫生—临床医学]