大鼠大脑中动脉缺血后环氧合酶-2表达的研究  

Expression of cyclooxygenase 2 following ischemic middle cerebral artery in rat

作　　者：黄海燕[1] 罗毅男 刘新华[2] 刘今是 刘勇[3] 刘英开 

机构地区：[1]长春白求恩医科大学一院神经外科,130021 [2]长春市中心医院干部病房 [3]镇赉县医院 [4]长春市自来水公司医院

出　　处：《中风与神经疾病杂志》1999年第5期275-276,共2页Journal of Apoplexy and Nervous Diseases

摘　　要：目的　研究大鼠大脑中动脉缺血后环氧合酶－２（ｃｙｃｌｏｏｘｙｇｅｎａｓｅ－２，ＣＯＸ－２）的表达。方法　采用栓线法制备大脑中动脉缺血模型，利用免疫组化方法检测ＣＯＸ－２ 表达情况。结果　脑缺血区的周围大脑皮质及远隔的海马回区域有ＣＯＸ－２ 蛋白质表达。结论　在ＣＯＸ－２Objective Made ischemic models of middle cerebral artery in rat and expression of cyclooxygenase 2. Methods Thread technique was used to make ischemic models of middle cerebral artery and measure expression of cyclooxygenase 2 by immun ohistochemistry. Result There was expression of cyclooxygenase 2 in surroundings cortex of cerebral ischemia and remote hippocampus. Conclusion accelerae metabolism of arachidonic acid can be in these regions.

关 键 词：环氧合酶-2 花生四烯酸 局灶性 脑缺血 大鼠 

分 类 号：R743.310.2[医药卫生—神经病学与精神病学]