神经上皮性肿瘤^(18)F-FDG摄取水平与VEGF表达及微血管密度的相关性  

Correlation Studies of ^(18)F-FDG Uptake with VEGF Expression and Microvessel Density in Neuroepithelioma

作　　者：蔡莉[1] 高硕[1] 李彦生[1] 杨海磊[1] 刘磊[1] 

机构地区：[1]天津医科大学总医院PET/CT中心,300052

出　　处：《天津医药》2011年第4期309-311,385,共4页Tianjin Medical Journal

基　　金：天津市高等学校科技发展基金项目(项目编号:20050232)

摘　　要：目的:探讨神经上皮性肿瘤18F-脱氧葡萄糖(18F-FDG)摄取水平与血管内皮生长因子(VEGF)表达及肿瘤微血管密度(MVD)间的相关性。方法:对41例神经上皮性肿瘤的患者行18F-FDG正电子发射断层显像(PET)检查,肿瘤标本采用免疫组化染色,检测VEGF表达及肿瘤MVD。按VEGF表达高低将其分为2组并观察VEGF低表达和高表达组间18F-FDG的肿瘤与对侧蛋白质的SUV比值(T/WM)的差异,T/WM与MVD间的相关性。结果:41例患者中VEGF低表达者23例,VEGF高表达者18例。VEGF低表达组与VEGF高表达组T/WM值差异有统计学意义(P<0.05)。T/WM与MVD呈正相关(r=0.759,P<0.05)。结论:神经上皮性肿瘤的18F-FDG摄取水平与VEGF表达及MVD之间存在一定关联,可用于术前活体评估肿瘤的血管生成情况。Objective： To investigate the correlation of 18F-FDG uptake with vascular endothelial growth factor （VEGF） protein expression and microvessel density （MVD） in neuroepithelioma. Methods： 18F-FDG PET examinations were performed preoperatively in 41 patients with suspected neuroepithelioma. Immunohistochemical stain method was used to demonstrate the situation of VEGF expression and the MVD in tumors. According to the situation of VEGF expression, all cases were divided into two groups including low VEGF expression group and high VEGF expression group. Mann-Whitney U test was used for comparing the difference in 18F-FDG between the two groups. The spearman correlation analysis was used for observing the correlation between T/WM and MVD. Results： There were 23 patients with low VEGF expression, and 18 with high VEGF expression in 41 patients with neuroepithelioma. The values of T/WM were significantly different between the low VEGF expression group （ranged from 0.62-3.04） and high VEGF expression group （ranged from 1.29-7.64, P 0.05）. The value of T/WM was positively correlated with MVD （r = 0.759,P 0.05）. Conclusion： There were correlations between the level of 18F-FDG, VEGF and MVD in neuroepithelioma. It is feasible to evaluate the microvessel angiogenesis in vivo using the level of 18F-FDG uptake in neuroepithelioma.

关 键 词：肿瘤 神经上皮 氟脱氧葡萄糖F18 正电子发射断层显像术 血管内皮生长因子类 免疫组织化学 新生血管化 病理性 

分 类 号：R730.44[医药卫生—肿瘤]