肺癌化疗前后生活质量及抑郁情绪改变分析  

Investigation of the Change of Quality of Life and Depression in Lung Cancer Patients before and after Chemotherapy

作　　者：曹建存[1] 王燕[2] 张丽[1] 马力[2] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津医科大学总医院肿瘤科,天津300052

出　　处：《中国肺癌杂志》2011年第4期358-361,共4页Chinese Journal of Lung Cancer

摘　　要：背景与目的生活质量是癌症患者一个重要的观察终点,抑郁情绪更易出现在肺癌患者中。本研究旨在了解化疗对生活质量及抑郁情绪的影响。方法随机抽取住院化疗的肺癌患者40例,分别于化疗前、化疗2周期后1周内、化疗4周期后1周内评估临床疗效,并进行EORTC QLQ-C30问卷、Zung抑郁自评量表问卷调查。结果化疗前,生活质量功能领域、疲乏、呼吸困难条目得分较高,有抑郁情绪的占65%;化疗2周期后,化疗有效率为42.5%,认知功能条目得分上升,角色、情绪、社会功能条目得分下降,呼吸困难得分下降,疼痛、食欲不振、失眠、便秘、腹泻条目得分上升,整体生活质量下降,有抑郁情绪的占70%;化疗4周期后,化疗有效率为23%,躯体、角色、情绪、社会功能得分下降,症状领域各条目得分均上升,呼吸困难、恶心呕吐、食欲不振、经济影响条目得分上升,整体生活质量下降,有抑郁情绪的者占87.5%。结论部分肺癌患者经化疗后症状得到缓解,但化疗过程中,抑郁情绪明显,生活质量下降,应及时评价患者生活质量及情绪改变,并给予积极心理干预,以提高患者生活质量。Background and objective Quality of life（QoL） is an important end point in cancer patients,and depressive symptoms are significantly more frequent in lung cancer patients. The aim of this study is to observe the impact of chemotherapy on quality of life and emotion among lung cancer patients. Methods Fourty lung cancer patients were as-sessed with clinical outcomes,the EORTC QLQ-C30,SDS questionnaires before chemotherapy,one week after 2 cycles of chemotherapy,one week after 4 cycles of chemotherapy. Results Before chemotherapy,the scores of functioning scales were high,the rate of depression was 65%. After 2 cycles of chemotherapy,effective rate was 42.5%,the scores of cognitive function increase,the scores of role,emotional,social function decrease,the scores of dyspnoea decrease,the scores of pain,appetite loss,insomnia,constipation,diarrhea increase,the scores of Global quality of life decrease;the rate of depression was 70%. Af-ter 4 cycles of chemotherapy,effective rate was 23%,the scores of physical,role,emotional,social function decrease,the scores of symptom scales increase,the scores of dyspnoea,nausea and vomiting,appetite loss,financial impact increase,the scores of global quality of life decrease,the rate of depression was 87.5%. Conclusion Some patients have symptoms relieved,but dur-ing the chemotherapy,the patients have significant depression,the quality of life decrease. We should evaluate the quality of life and emotions of lung cancer patients,and give positive psychological intervention to improve the quality of life.

关 键 词：肺肿瘤 化疗 生活质量 抑郁 

分 类 号：R734.2[医药卫生—肿瘤]