二味康口服液对荷瘤小鼠免疫功能的影响  

Immunological activities of Erweikang oral solution on mice bearing Lewis lung cancer

作　　者：马宝瑕[1] 李俊[2] 王斌[2] 尹银嘉[1] 魏世超[1] 

机构地区：[1]同济医科大学同济医院,武汉430030 [2]安徽医科大学临床药理所

出　　处：《中国医院药学杂志》1999年第10期581-584,共4页Chinese Journal of Hospital Pharmacy

摘　　要：探讨二味康口服液抗癌及免疫调节机理。方法：采用二味康口服液不同剂量对荷Lewis肺癌小鼠进行实验。结果：二味康口服液治疗给药可使荷瘤小鼠低下的T、B淋巴细胞增殖反应，脾细胞产生IgM，血清中IgG含量及脾细胞产生IL-2恢复至接近正常水平，并促进荷瘤小鼠腹腔巨噬细胞产生IL-1和TNF。结论：二味康口服液属中药BRM（生物反应调节剂）范畴，其抗癌作用与其增强免疫功能有关。To study the immunological machanism of antitumor activity of Erweikang(EWK) oral solution.METHODS: Immunologycal activity of EWK on mice bearing Lewis lung cancer(LLC) was investigated. RESULTS: EWK could re-convrt the low T. B. proliferous response, IgM, IgG and IL-2 to be cose to normal level, and promote IL-I and TNF preduced byPeritoneae macrophage. CONCLUSIONS: EWK belongs to the BRM of Chinese Medicine. The antitumor activity of EWK might beassociatcel eith improving the function of immune system of mice bearing LLC.

关 键 词：二味康口服液 免疫功能 LEWIS肺癌 小鼠 

分 类 号：R734.2[医药卫生—肿瘤] R979.1[医药卫生—临床医学]