复方甘草酸苷治疗药物性肝脏损害的临床观察  

Clinical Observation on Glycyrrhizin Anhydride in the Treatment of Drug-induced Liver Damage

作　　者：许尔屹[1] 王东伟[1] 薛峰[1] 刘丹丹[1] 

机构地区：[1]黑龙江省医院肿瘤科,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2011年第4期272-274,共3页Heilongjiang Medical Journal

摘　　要：目的探讨复方甘草酸苷(美能)治疗药物性肝脏损害的效果。方法回顾性分析48例诊断明确且排除转移性肝癌及原发性肝癌的恶性肿瘤病人,将其随机分为两组:治疗组25例,采用美能注射液60 mL,加入5%葡萄糖注射液250 mL中,静脉滴注,1次/d,3周后复查肝功能;对照组23例,采用肌苷0.4 g,维生素C5.0 g,加入5%葡萄糖注射液250 mL中,静脉滴注,1次/d,3周后复查肝功能。结果治疗组3周后,血清ALT、AST、TB、γ-GT明显下降;与对照组相比,平均下降水平有显著差异(P<0.05)。结论复方甘草酸苷对药物性肝脏损害有较好的防治作用。Objective To probe into the result of compound glycyrrhizin in treating drug induced liver disease.Methods The analysis of retrospective cases： To divide 48 cases of tumour Patients who are diagnosed,but precluded the Metastatic Liver Cancer and primary carcinoma of the Liver into 2 groups.The Therapitic Group includes 25 cases.We adopt vein transfusion of 60 ml of SNMC and 250 mL of 5% glucose injection one time per day and check the liver function three weeks later.The control group includes 23 cases.We adopt vein transfusion of 0.4g of Inosine,5.0g vitamin C and 250 mL of 5% glucose injection one time per day and check the liver function three weeks later.Results In the therapitic group,the levels of serum,ALT,AST,TB,γ-GT decline obviously.Compared with the control group,there are remarkable differences of the average declining level（P0.05）.Conclusion Compound glycyrrhizin has better prevention and cure function in treating drug induced liver disease.

关 键 词：复方甘草酸苷 肌苷 化学治疗 药物性肝脏损害 

分 类 号：R575.1[医药卫生—消化系统]