连续电除颤与单次电除颤在长时程心室颤动中的疗效对比研究  

Comparison of effects of continuous and one-shock defibrillations on a canine model of prolonged ventricular fibrillation

作　　者：王伯松[1] 钟敬泉[1] 李景莎[1] 曾绮娴[1] 刘红臻[1] 苏国英[1] 刘东林[1] 张运[1] 

机构地区：[1]山东大学齐鲁医院心内科,济南250012

出　　处：《山东大学学报（医学版）》2011年第3期37-40,45,共5页Journal of Shandong University:Health Sciences

基　　金：高等学校博士学科点专项科研基金资助项目(20100131110059)

摘　　要：目的评价连续电除颤与单次电除颤在长时程心室颤动(室颤)中的抢救效果。方法将24只犬采用体外电击法制备室颤动物模型,室颤维持8 min后,将动物随机分为连续电除颤组和单次电除颤组。连续或单次电除颤后立即进行2min心肺复苏,循环以上抢救步骤,直至动物复苏成功或抢救时间超过15min。记录两组动物的复苏延搁时间、复苏成功率、复苏后血流动力学参数以及左室射血分数。结果与连续电除颤组相比,单次电除颤组在整个心肺复苏过程中的复苏延搁时间明显减少(P<0.05),复苏成功率明显提高(P<0.05),复苏后的冠脉灌注压和射血分数均较高(P均<0.05)。结论对于长时程室颤的抢救,单次电除颤的效果明显优于连续电除颤。Objective To investigate effects of continuous and one-shock defibrillations on prolonged ventricular fibrillation（VF）.Methods VF was electrically induced in 24 dogs.After 8 min of untreated VF,the animals were randomly divided into the continuous shock group and the one-shock group.After continuous or one-shock defibrillation,the animals were given 2 min of cardiopulmonary resuscitation（CPR）.The process of rescue continued until the animals attained return of spontaneous circulation（ROSC） or it lasted for 15 min.Time of CPR interruptions,rates of ROSC,hemodynamic variables and the left ventricular ejection fraction（LVEF） were recorded.Results Compared with the continuous shock group,animals in the one-shock group had significantly shorter time of CPR interruptions（P0.05）,improved rate of ROSC（P0.05）,and higher coronary perfusion pressure and LVEF（both P0.05）.Conclusion The effect of one-shock defibrillation on prolonged VF is significantly better than that of continuous shock defibrillation.

关 键 词：心室颤动 模型 动物 心肺复苏 电除颤 

分 类 号：R541.78[医药卫生—心血管疾病] R-332[医药卫生—内科学]