胶质肉瘤的临床特点与治疗（附九例报告及文献复习）  

Clinical features and treatment of gliosarcoma： report of nine cases and literature review

作　　者：王宏伟[1] 刘玉光[1] 

机构地区：[1]山东大学齐鲁医院神经外科,济南250012

出　　处：《中华神经外科杂志》2011年第4期494-497,共4页Chinese Journal of Neurosurgery

摘　　要：目的 总结胶质肉瘤的临床特点及治疗.方法 报道9例胶质肉瘤,综合7组文献资料针对该病的组织起源、临床特点、诊断、治疗及预后等进行分析.结果 该病具有以下特点：（1）男女之比为2.1∶1,平均年龄46岁;（2）以亚急性颅内压增高为主要临床表现;（3）11%发生颅外转移;（4）绝大多数位于幕上大脑半球凸面,常累及2个或2个以上脑叶,以颞顶或额顶最多见;（5）多数边界清楚,少数与硬脑膜、颅骨关系密切,呈均匀明显强化可误诊为脑膜瘤;（6）平均生存期一般在7-10个月.结论 易侵犯脑膜、颅骨及发生颅外转移是其显著临床特点之一,确诊有赖于免疫组化染色,手术切除是首选治疗方法,预后极差.Objective To sunnarize the clinical features and treatment of gliosarcomas （GSs）.Method Ninecases of GSs were reported and 7 groups of GSs reported in literatures were analyzed on the histogenesis, clinical features, diagnosis, treatment and prognosis. Results The clinical characteristics of GSs increaesed intracranial pressure. （3）Extracranial metastasis occurred in 11% of GSs. （4） Most of GSs located in the supratentorial cerebral convex and often invaded two or more lobes, especially the temproprietal and frontoprietal lobes. （5） Most tumours had clear boundary, some attached to dura and skull bone, which were frequently misdiagnosed as meningiomas if they were enhanced markblely and homogeneously. （6）The mean survival period was usually from 7 to 10 months. Conclusions Invasion of dura and skull bone and extracranial metastasis are two significant clinical features of GSs. The confirmned diagnosis depends on immunohistochemical staining The surgical treatment is the first choice for GSs, but the prognoses is very poor.

关 键 词：胶质肉瘤 临床特点 治疗 

分 类 号：R739.4[医药卫生—肿瘤]