抽动秽语综合征的脑^99Tc^m-TRODAT-1SPECT显像  

Evaluation of Tourette＇s syndrome by ^99Tc^m-TRODAT-1 SPECT imaging

作　　者：董峰[1] 刘红[2] 孟召伟[1] 谭建[1] 张本恕[2] 

机构地区：[1]天津医科大学总医院核医学科,300052 [2]天津医科大学总医院神经内科,300052

出　　处：《中华核医学杂志》2011年第2期104-107,共4页Chinese Journal of Nuclear Medicine

摘　　要：目的 利用^99Tc^m-TRODAT-1 SPECT脑显像观察抽动秽语综合征（TS）患者纹状体DAT的结合能力,探讨纹状体^99Tc^m-TRODAT-1的摄取率与年龄、病程及抽动严重性之间的关系.方法 选取未经治疗的TS患者18例：男14例,女4例,年龄（24±10）岁;性别、年龄匹配的健康对照者8名.所有受检者按体质量静脉注射^99Tc^m-TRODAT-1 11.1～14.8 MBq/kg,2.5 h后行脑SPECT显像.分别在双侧纹状体及进一步划分的尾状核和壳核勾画感兴趣区,以小脑为本底,计算纹状体/小脑放射性比值,该值反映纹状体对99Tcm-TRODAT-1的摄取率.采用独立样本t检验将TS患者与对照组的99Tcm-TRODAT-1摄取率进行比较;采用Pearson相关分析将患者摄取率与年龄、病程、抽动严重性等做进一步相关分析.结果 TS患者双侧纹状体对99Tcm-TRODAT-1的摄取率明显高于对照组（2.17±0.23与1.87±0.24,t=2.957,P＜0.05）,且分布对称;纹状体摄取率与患者年龄（r=-0.320,P＞0.05）、抽动严重性（r=0.345,P＞0.05）无关,但与病程呈负相关（r=-0.483,P＜0.05）,病程越短,摄取率越高.结论 未经治疗的TS患者DAT功能活性较对照组明显增强;DAT活性增高程度与病程呈负相关.99Tcm-TRODAT-1 SPECT脑显像可作为初诊TS患者确诊的客观依据.Objective To observe dopamine transporter （DAT） binding capacity using 99Tcm-TRODAT-1 in drug-naive patients with Tourette＇s syndrome （TS） on SPECT imaging, and explore possible correlations between 99Tcm-TRODAT-1 uptake ratio and TS patient＇s age, disease duration, and tic severity.Methods Eighteen drug-naive TS patients, male 14, female 4, as well as 8 age- and gender-matched healthy subjects were recruited. Brain SPECT imaging was performed 2. 5 h after intravenous injection of 11.1 - 14.8 MBq/kg 99Tcm-TRODAT-1. ROI was drawn on the striatum including its sub-regions of caudate and putamen, with cerebellum as the background. Striatum/cerebellum ratio was calculated. Comparisons of the ratios between TS patients and controls were carried out by independent-sample t-test. Pearson correlation analysis was performed between DAT uptake ratios of striatum and patients＇ age, disease duration, tic severity. Results Compared with the control, higher symmetrically striatum uptake of 99Tcm-TRODAT-1 in TS patients was observed （2.17±0.23 vs 1.87±0.24, t =2.957, P〈0.05）. Age （r= -0.320, P〉0.05）and tic severity（r = 0. 345, P 〉 0.05） scores were not significantly correlated with specific uptake ratios measured in the striatum. But there was significant negative correlation between disease duration and the specific uptake ratios （r = - 0. 483, P 〈 0. 05）. Conclusions 99 Tcm-TRODAT-1 SPECT imaging may play an adjuvant role for initial evaluation of untreated TS.

关 键 词：多动秽语综合征 脑 多巴胺 TRODAT-1 体层摄影术 发射型计算机 单光子 

分 类 号：R749.94[医药卫生—神经病学与精神病学] R817.4[医药卫生—临床医学]