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作 者:闫彦[1] 刘慧迪[1] 曹雪峰[1] 谭培珠[1] 温海霞[1] 吕春梅[1] 李晓梅[2] 刘国艺[1]
机构地区:[1]哈尔滨医科大学生理教研室,哈尔滨150081 [2]哈尔滨医科大学附属第三医院病理科,哈尔滨150040
出 处:《生殖与避孕》2011年第4期236-240,共5页Reproduction and Contraception
基 金:黑龙江省自然科学基金(D201008);黑龙江省博士后启动基金(LRB04-248)资助
摘 要:目的:探索新型雌激素受体G蛋白耦联受体30(G protein coupled receptor 30,GPR30)在人上皮性卵巢癌发生发展中的作用。方法:采用免疫组织化学SP法检测30例上皮性卵巢癌组织中GPR30、增殖相关基因c-fos和cyclinD1的表达,并以9例良性卵巢肿瘤、4例正常卵巢组织作对照。结果:GPR30在上皮性卵巢癌的表达水平(80.0%)显著高于良性卵巢肿瘤(44.4%)和正常卵巢组织(25.0%)(P<0.01;P<0.05)。GPR30和c-fos的表达与上皮性卵巢癌的病理类型、FIGO分期有关,在浆液性囊腺癌、FIGOⅢ-Ⅳ期的表达水平显著升高(P<0.05)。未见cyclinD1的表达与上皮性卵巢癌临床病理参数的关系(P>0.05)。上皮性卵巢癌中GPR30与c-fos、cyclinD1的表达具有正相关性(P<0.01;P<0.05)。结论:GPR30可能通过c-fos、cyclinD1促进卵巢癌增殖,参与上皮性卵巢癌的发生、发展。Objective:To investigate the effect of G protein-coupled receptor 30(GPR30) in epithelial ovarian carcinoma(EOC).Methods:Immunohistochemistry was used to detect the expression of GPR30,c-fos and cyclinD1 in 30 cases of EOC,which was compared with 9 cases of benign ovarian tumor and 4 cases of normal ovarian tissue.Results:The over-expression rates of GPR30 in EOC,benign ovarian tumor and normal ovarian tissue were 80.0%(24/30),44.4%(4/9) and 25.0%(1/4),respectively.The expression of GPR30 was increased significantly compared with that in benign ovarian tumor or normal ovarian tissue(P0.01,P0.05).The expression of GPR30 and c-fos in EOC had a strong relationship with pathological type and FIGO stage,as there was a higher over-expression rate in serous EOC and FIGO Ⅲ-Ⅳ(P0.05),but there were no significant differences of cyclinD1 expression among ages,pathological types and FIGO stages(P0.05).In addition,the expression of GPR30 was positively correlated with c-fos and cyclinD1 in EOC(P0.01,P0.05).Conclusion:GPR30 might be involved in tumorigenesis and development of EOC by activating c-fos and cyclinD1 to stimulate proliferation of ovarian carcinoma.
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