CD147、MMP-2 mRNA在胃癌组织中的表达及临床意义  

The expression and clinical significance of the CD147 and MMP-2 mRNA in gastric carcinoma

作　　者：赖丽琴[1] 张红[1] 吴倩[1] 秦蓉[1] 

机构地区：[1]安徽医科大学病理学教研室,合肥230032

出　　处：《安徽医科大学学报》2011年第5期416-419,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教育厅自然科学基金(编号:2005KJ259)

摘　　要：目的探讨CD147及基质金属蛋白酶-2(MMP-2)mRNA在胃癌组织中的表达及其意义。方法应用原位杂交方法检测76例石蜡包埋胃癌组织及20例癌旁正常胃黏膜中CD147和MMP-2 mRNA的表达情况。结果 CD147和MMP-2 mRNA在胃癌组织中的阳性表达率分别为69.7%、75.0%,与癌旁正常胃黏膜比较差异均有统计学意义(P<0.01)。CD147和MMP-2 mRNA阳性表达与肿瘤的大小、浸润深度、淋巴结转移有关(P<0.05),与患者的性别、年龄、肿瘤的分化程度无关。CD147和MMP-2 mRNA在胃癌组织中的表达具有相关性(P<0.01)。结论 CD147和MMP-2 mRNA的表达与胃癌的浸润和转移有关,可以作为胃癌进展和预后的指标。Objective To investigate the significance of CD147 and matrix metalloproteinase-2（MMP-2） mRNA expression in human gastric carcinoma.Methods CD147 and MMP-2 mRNA expression was assessed in paraffin-embedded specimens collected from 76 cases of gastric carcinoma and 20 cases of adjacent normal tissues by in situ hybridization methods.Results The positive rate of expression of CD147 and MMP-2 mRNA in gastric carcinoma was 69.7%,75.0%,respectively.The expression of CD147 and MMP-2 mRNA was both strongly related to the tumor size,depth of invasion and lymph nodes metastasis of gastric carcinoma（P〈0.05）.However,CD147 and MMP-2 mRNA had no significant difference with pathological grades,age and gender.There was a significant relationship between expressions of CD147 and MMP-2 mRNA（P〈0.01）.Conclusion CD147 and MMP-2 play an important role in the invasion and metastasis in gastric carcinoma.They might be good markers for development and prognosis of gastric carcinoma.

关 键 词：胃肿瘤 抗原 CD147 基质金属蛋白酶2 原位杂交 

分 类 号：R735.2[医药卫生—肿瘤] R345[医药卫生—临床医学]