gp96和c-jun在结直肠癌组织中的表达及临床意义  

Expression and clinical significance of gp96 and c-jun in colorectal carcinoma

作　　者：刘传磊[1] 邓跃华[1] 刘弋[1] 李帅[1] 

机构地区：[1]安徽医科大学第一附属医院普外科,合肥230022

出　　处：《安徽医科大学学报》2011年第5期423-426,共4页Acta Universitatis Medicinalis Anhui

摘　　要：目的探讨糖蛋白96(gp96)和c-jun在结直肠癌组织中的表达及临床意义。方法采用免疫组化法检测78例结直肠癌患者术后肿瘤组织及癌旁组织标本中gp96和c-jun的表达。结果 gp96和c-jun在肿瘤组织中的表达均高于癌旁组织(P<0.05)。gp96的表达与肿瘤分化程度、结直肠癌淋巴结转移、侵犯肠壁深度及Dukes分期有关(P<0.05)。c-jun的表达与结直肠癌分化程度有关(P<0.05)。在高分化结直肠癌中gp96和c-jun的表达存在关联(P<0.05)。单因素分析示影响结直肠癌术后总体生存率的因素有肿瘤大小、侵犯肠壁程度、有无淋巴结转移、Dukes分期和gp96的表达状态。结论结直肠癌组织中gp96和c-jun表达显著增高,且在高分化癌中两者可能有协同作用,gp96的表达可判断预后。Objective To study the expression and significance of the gp96 and c-jun in colorectal cancer.Methods The expression of gp96 and c-jun were assessed in 78 speciments of colorectal cancer and their adjacent normal mucosa by immunohistochemistry.Results The expression of gp96 and c-jun in colorectal cancer were higher than those in their adjacent normal mucosa（P〈0.05）.The expression of gp96 was related to the differentiation,depth of invasion,lymph node metastasis and Dukes stage（P〈0.05）.The expression of c-jun was related to differentiation grade（P〈0.05）.The expression of gp96 was positively correlated with the expression of c-jun in well-differentiated colorectal cancer（P〈0.05）.Univariate analysis indicated that factors affecting overall survival were tumor size,depth of invasion,lymph node metastasis,Dukes stage and expression status of gp96 in colorectal cancer.Conclusion The expression of gp96 and c-jun are significantly increased in colorectal cancer,and which may have a synergistic effect in well-differentiated colorectal cancer,and the positive expression of gp96 can affect prognosis of colorectal cancer.

关 键 词：糖蛋白类 原癌基因蛋白质c-jun 结直肠肿瘤 预后 

分 类 号：R735.3[医药卫生—肿瘤] R341[医药卫生—临床医学]