淋巴系统肿瘤发病与EB病毒和IL-10基因多态性的关系  

Association of Lymphoid Malignancy Incidence with EB Virus and IL-10 Gene Polymorphism——Review

作　　者：王慈[1,2] 潘凌[2] 朱平[1] 

机构地区：[1]北京大学第一医院血液研究室,北京100034 [2]河北医科大学第二医院血液科,河北石家庄050000

出　　处：《中国实验血液学杂志》2011年第2期528-531,共4页Journal of Experimental Hematology

基　　金：科技部国际科技合作重大项目(编号2006DFB31430);863高科技项目(编号2008AA062503)

摘　　要：淋巴系统肿瘤与病毒感染有密切关系,EBV(Epstein-Barr Virus)转染正常B细胞会造成B细胞发生类似肿瘤的永生化,是最可疑的致病因素。EBV的Bcrf1编码框又称为病毒IL-10,和人类IL-10同源,具有和IL-10相似的免疫抑制作用。IL-10是一种重要的免疫调节因子,其分泌水平的高低影响着淋巴系统疾病的发生和发展;IL-10启动子区的SNP位点基因型也与IL-10的分泌水平相关。本综述探讨淋巴系统肿瘤,EBV感染以及IL-10基因多态性之间的密切关系。EBV（Epstein-Barr Virus） is a common herpes virus in patient with lymphatic system tumor,which firstly discovered in the cell line of Burkitt′s lymphoma.90% people worldwide had been infected by EB virus before grown-up,but not all people have the EBV-related disease or tumor.Most EBV infection can not elicit clinical symptoms.EBV infection in tumor of lymphatic system is common.It was early known that the EBV existence may cause the immortalization of normal B cells,which like the tumor cells.It means that EBV plays an important role in the tumorigenesis.EBV Bcrf1 code frame is homology to human IL-10,which is also called viral IL-10,showing immunosuppressive effect similar to the IL-10.IL-10 is also an important immunoregulatory factor,the secretory level of which influences the occurrence and development of lymphatic system deseases;the genotype of SNP site in IL-10 promoter region also associates with secretory level of IL-10.This review disccuses the close relation between tumor of lymphatic system,EBV infection and gene polymorphison of IL-10.

关 键 词：淋巴系统肿瘤 IL-10 单核苷酸多态性 EB病毒 

分 类 号：R733.1[医药卫生—肿瘤] R373[医药卫生—临床医学]