信号转导通路在非霍奇金淋巴瘤中的作用研究进展  

Roles of Signal Transduction Pathway in Non-Hodgkin′s Lymphoma——Review

作　　者：张希远[1] 王欣[1] 

机构地区：[1]山东大学附属省立医院血液科,山东济南250021

出　　处：《中国实验血液学杂志》2011年第2期532-536,共5页Journal of Experimental Hematology

基　　金：山东省科技发展计划项目(编号2007GG10002008);山东省自然科学基金(编号Y2007C053);(编号ZR2009CM059)

摘　　要：信号通路(signal pathway)的研究已逐渐发展成为生命科学科研领域的热点和重点。愈来愈多的证据表明,信号通路与多种肿瘤的发生、发展、预后及耐药密切相关,在非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)中也具有显著的相关性。阐明信号传导通路的生物学功能及其与NHL的关系,选择性地调控该生物学活性可能为NHL的治疗提供一个新的途径。为进一步了解信号转导在NHL发病机制及发生、发展、治疗及预后中的影响,本文将根据近年来NHL病例的相关报道,结合信号通路诸如核转录因子κB信号通路、PI3K信号通路、Notch信号通路、Hh信号通路、MAPK信号通路、JAK-STAT信号通路、Wnt信号通路、cAMP信号通路等进行系统性综述。The study of signal pathway has become a hotspot and a key in life science.In recent years,it has been found that many signaling pathways are associated with the occurrence,development,prognosis and drug resistance of many malignancies,including non-Hodgkin′s lymphoma（NHL）.Understanding the biological function of the signaling pathway and its relation with NHL,selectively controling its biological activities may provide a new way for the treatment of NHL.In order to further investigate the function of signal pathways in pathogenesis,development and treatment of NHL,this review summarizes briefly the advances in the signal pathways related with the NHL including NF-κB,PI3K-AKT,Notch,Hh,MAPK,JAK-STAT,Wnt and cAMP.

关 键 词：淋巴瘤 信号通路 非霍奇金淋巴瘤 

分 类 号：R733.1[医药卫生—肿瘤]