CD44水解片段的释放及其功能  

Release of CD44-proteolytic Fragments and their Functions——Review

作　　者：陈大燕[1] 冯茹[1] 

机构地区：[1]南方医科大学南方医院血液科,广东广州510515

出　　处：《中国实验血液学杂志》2011年第2期554-556,共3页Journal of Experimental Hematology

摘　　要：CD44是一种广泛表达的细胞表面黏附分子并参与细胞多种生物活动。CD44在酶作用下可发生有序的蛋白水解。CD44的水解程度与细胞活性有关,其水解后片段包括可溶性CD44(soluble CD44,sCD44)和CD44胞内结构域(CD44 intracellular domain,CD44ICD),二者在细胞生命活动中发挥不同作用。近年对CD44水解及水解后片段进行了深入的研究,本文就CD44水解及水解后片段的功能进行综述。CD44 is a widely distributed cell-adhesion molecule that participates in a number of biological events.CD44 is proteolytically cleaved by other enzymes and the level of its proteolysis is correlated to the cell activity.The CD44-proteolytic peptides including soluble CD44 and CD44 intracellular domain have different functions in cell events.In recent years,a number of researches found the functions of CD44-proteolytic peptides.In this review,the release of CD44-proteolytic peptides and their functions of these peptides were summarized.

关 键 词：CD44 蛋白水解 可溶性CD44 CD44胞内结构域 

分 类 号：R730.2[医药卫生—肿瘤]