Effects of selenium on electrophysiological changes associated with diabetic peripheral neuropathy  

作　　者：Murat Ayaz Hülagu Kaptan 

机构地区：[1]Department of Biophysics,Seluklu Medical Faculty,Selcuk University [2]Department of Neurosurgery,Seluklu Medical Faculty,Selcuk University

出　　处：《Neural Regeneration Research》2011年第8期617-622,共6页中国神经再生研究（英文版）

基　　金：Supported by:the Scientific Committee Foundation of Selcuk University (BAP Project No.06401013),Konya,Turkey

摘　　要：Our previous study has demonstrated that sodium selenite prevents oxidative stress, suggesting that selenium can improve diabetic peripheral neuropathy. Results from this study demonstrated that diabetes mellitus resulted in significant increased time to peak, as well as rheobase and chronaxie values. In addition, maximum depolarization, area under compound action potential, kinetics, and conduction velocities of fast and slow nerve fiber groups were decreased. Sodium selenite exhibited positive effects on alterations of diabetes mellitus-induced conduction velocity distribution. This neuroprotective effect was primarily observed in the area under compound action potential and compound action potential kinetic waveforms, as well as rheobase and chronaxie. Results from this study showed that selenium supplementation blocked the diabetes mellitus-induced shift of actively contributing nerve fibers, and restored levels towards age-matched control group values. Chronic selenate supplementation for experimental diabetic peripheral neuropathy exhibited protective effects in measured electrophysiological parameters.Our previous study has demonstrated that sodium selenite prevents oxidative stress, suggesting that selenium can improve diabetic peripheral neuropathy. Results from this study demonstrated that diabetes mellitus resulted in significant increased time to peak, as well as rheobase and chronaxie values. In addition, maximum depolarization, area under compound action potential, kinetics, and conduction velocities of fast and slow nerve fiber groups were decreased. Sodium selenite exhibited positive effects on alterations of diabetes mellitus-induced conduction velocity distribution. This neuroprotective effect was primarily observed in the area under compound action potential and compound action potential kinetic waveforms, as well as rheobase and chronaxie. Results from this study showed that selenium supplementation blocked the diabetes mellitus-induced shift of actively contributing nerve fibers, and restored levels towards age-matched control group values. Chronic selenate supplementation for experimental diabetic peripheral neuropathy exhibited protective effects in measured electrophysiological parameters.

关 键 词：sciatic nerve diabetic neuropathy STREPTOZOTOCIN conduction velocity distribution sodium selenite 

分 类 号：R587.2[医药卫生—内分泌]