纳米颗粒在石英晶体微天平生物传感器中的应用与研究进展  

Development and Application of Nanoparticles in Quartz Crystal Microbalance Biosensor

作　　者：冯阳阳[1] 李杜娟[1] 叶尊忠[1] 王剑平[1] 

机构地区：[1]浙江大学生物工程与食品科学学院,杭州310029

出　　处：《中国生物医学工程学报》2011年第2期299-307,共9页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(20907041)

摘　　要：得益于快速、简便、可在线分析的优点,石英晶体微天平生物传感器在生物、医学、食品安全分析、环境和军事等领域都有着重要的应用价值,但灵敏度和再生能力等性能的不足仍限制其走出实验室获得实际应用,纳米颗粒的引入有望解决这一难题。纳米颗粒表面活性位点多,生物兼容性好,非常适宜于生物化学分析检测。在石英晶体微天平生物传感器中,纳米颗粒可作为载体固定敏感分子;作为标记物放大检测信号;还可在磁场的辅助下提高传感器的再生能力和缩短检测时间。文中结合近年来国内外最新研究进展,对这三个方面进行了详细的评述,并探讨了未来的发展趋势。Owing to the merits of fast screening,simple and online analytical processing,quartz crystal microbalance biosensors have extensive application for numerous biomedical applications and many other industry purposes.However,the insufficient sensitivity and regeneration ability restrict its laboratory application.Nanoparticles with fascinating properties such as high surface area,considerable amount of surface active centers and excellent absorption ability are the optimal candidates for its use in the development of highly sensitive quartz crystal microbalance（QCM） biosensors.Over the last decade,a great deal of research work apply nanoparticles to improve the performance of QCM biosensors,such as applying them as solid support to immobilize the sensitive molecules and as label to enhance the frequency response.Furthermore,magnetic nanoparticles could enhance the regeneration ability and shorten the detection time simultaneously.This article aims to provide a general overview of the possible application of nanoparticles and highlights the application strategies of nanoparticles in the QCM biosensors.Limitations and further development tendencies have also been discussed here.

关 键 词：纳米颗粒 石英晶体微天平 生物传感器 

分 类 号：R318[医药卫生—生物医学工程]