脑肿瘤患者认知功能障碍的研究  

Study of cognitive dysfunction before and after operation in patients with cerebral tumors

作　　者：余汉辉[1] 周东[2] 彭龙[1] 詹升全[2] 李昭杰[2] 林志俊[2] 林晓风[2] 侯庆石[1] 

机构地区：[1]南方医科大学 [2]广东省人民医院神经外科,广州510080

出　　处：《中国临床神经外科杂志》2011年第4期193-195,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨脑肿瘤患者认知功能障碍的特点和手术对它的影响。方法采用中文版蒙特利尔认知评估量表(MoCA)对100例脑肿瘤患者的认知功能进行术前、术后评估,并进行统计学分析。结果脑肿瘤患者认知功能损害率术前为48.0%,术后为62.0%,术后明显重于术前(P<0.05),术后以记忆能力(MEM)和注意能力(ATT)下降明显(P<0.05)。额颞叶肿瘤组认知功能损害率重于非额颞叶肿瘤组(P<0.05),额颞叶肿瘤组患者的视空间与执行能力、MEM、ATT和语言能力比非额颞叶肿瘤组患者损害更明显(P<0.05)。左右大脑半球脑肿瘤患者认知功能损害情况差异无统计学意义(P>0.05)。结论脑肿瘤患者认知功能损害是广泛的。手术可加重患者的认知功能损害。MoCA对脑肿瘤患者认知功能评估有较高的灵敏度。Objectives To explore the features of cognitive dysfunction of the patients with cerebral tumors and effect of surgery on it.Methods The preoperative and postoperative cognitive function were assessed by the Montreal Cognitive Assessment （MoCA） and statistically analyzed in 100 patients with cerebral tumors.Results The incidences of cognitive dysfunction in the patients with cerebral tumors were 48.0% and 62.0% respectively before and after surgery.The incidence of the cognitive dysfunction was significantly higher after the operation than that before the operation （P0.05）.The incidence （61.7%,37/60） of cognitive dysfunction in the patients with frontal and/or temporal tumors was significantly higher than that （30.0%,12/40） in patients with the non-frontal and non-temporal tumors （P0.05）.And the visuospatial and executive,memory,attention and language functions impairment in the patients with frontal and/or temporal tumors were significantly more severe than that in the patients with non-frontal and non-temporal tumors （P0.01）.The incidence （70.3%,26/37） of cognitive dysfunction in the patients with left hemisphere tumors was insignificantly higher than that （53.5%,23/43） in the patients with right hemisphere tumors （P0.05）.Conclusions There is cognitive dysfunction in the patients with cerebral tumors,in whom,the cognitive dysfunction may be worsened by surgery.MoCA is a sensitive method to assess the cognitive dysfunction in the patients with cerebral tumors.

关 键 词：脑肿瘤 认知功能障碍 蒙特利尔认知评估量表 

分 类 号：R739.41[医药卫生—肿瘤]