自由基清除剂对颅底肿瘤术后血清ET-1和IL-1β水平的影响  

Effect of free radical scavenger on serum levels of ET-1 and IL-1β in the patients with cranial bases tumors after surgery

作　　者：王和平[1] 高宝成[2] 李想[1] 陈坚[1] 

机构地区：[1]华中科技大学同医学院附属同济医院神经外科,武汉430030 [2]广州军区武汉总医院神经外科,武汉430070

出　　处：《中国临床神经外科杂志》2011年第4期217-219,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨自由基清除剂对颅底肿瘤术后血清内皮素(ET-1)及白细胞介素1β(IL-1β)的影响及其意义。方法将64例颅底肿瘤患者按随机数字表随机分为常规治疗组和抗自由基组,另以32例大脑表面肿瘤患者作为对照,对照组及常规治疗组采用常规治疗,抗自由基组在常规治疗基础上术中使用依达拉奉灌洗液冲洗,并在术后使用依达拉奉注射液30mg静脉滴注,2次/d,在手术治疗前后抽取静脉血检测ET-1及IL-1β水平。结果与对照组相比,常规治疗组术后ET-1及IL-1β明显升高(P<0.05),术后5～7d达到最高峰,然后下降,而抗自由基组术后ET-1及IL-1明显低于常规治疗组(P<0.05),但仍高于术前。结论颅底肿瘤术后的脑血管痉挛可能与血清ET-1及IL-1升高有关,抗自由基治疗可能通过降低颅底肿瘤患者术后血清ET-1和IL-1水平达到保护脑血管的作用。Objective To explore the effect of free radical scavenger on the serum levels of endothelin-1 （ET-1） and interleukin-1 β （IL-1β） after the surgery and its meanings in the patients with cranial bases tumors.Methods Sixty-four patients with cranial bases tumors were randomly divided into both the routine treatment （not treated by free radical scavenger） and edaravone treatment groups.Thirty-two patients with cerebral convex lesions,who did not received free radical scavenger treatment,served as control group.Edaravone treatment included that the operated areas were irrigated with the fluid containing edaravone in the operation and the edaravone was injected into the peripheral veins after the operation.The serum levels of ET-1 and IL-1β were determined before and after the operation in all the patients.Results The serum levels of ET-1 and IL-1s levels were significantly higher in the routine treatment group than those in the control group after the operation （P0.05）,they reached a peak 5～7 days after the operation,and then decreased gradually.The postoperative serum levels of ET-1 and IL-1β were significantly lower in edaravone treatment group than those in the routine treatment group （P0.05）,but they were significantly higher than those in the control group （P0.05）.Conclusions The increase in the serum levels of ET-1 and IL-1β after the operation may be decreased by free radical scavenger treatment in the patients with cranial bases tumors.It is suggested that the free radical scavenger may be of the protective effect on the cerebral vessels because the increase in the serum levels of ET-1 and IL-βmay be related to the cerebral vasospasm after the operation in the patients with cranial bases tumors.

关 键 词：自由基清除剂 颅底肿瘤 内皮素 白介素 脑血管痉挛 

分 类 号：R739.45[医药卫生—肿瘤] R739.41[医药卫生—临床医学]