放射性粒子组织间植入治疗口腔颌面-头颈部腺源性恶性肿瘤近期疗效分析  

Radioactivity seeds interstitial brachytherapy treating malignant salivary gland tumors

作　　者：张杰[1] 郑磊[1] 黄明伟[1] 刘树铭[1] 贾凌飞[1] 石妍[1] 俞光岩[1] 张建国[1] 

机构地区：[1]北京大学口腔医学院.口腔医院颌面外科,北京100081

出　　处：《北京大学学报（医学版）》2011年第2期272-275,共4页Journal of Peking University:Health Sciences

摘　　要：目的：回顾分析单独应用125I放射性粒子组织间植入近距离放疗治疗口腔颌面-头颈部腺源性恶性肿瘤的近期疗效。方法：2001年至2008年北京大学口腔医院颌面外科头颈部腺源性恶性肿瘤患者43人,因全身或局部因素不能进行手术切除,肿瘤部位包括腮腺、舌、上颌、颌下、咽旁、颅底颞下凹和口底。肿瘤直径为28 cm。本组患者均采用了单独125I放射性粒子组织间植入治疗,粒子活度2.59×1072.96×107Bq（0.70.8 mCi）,周缘匹配剂量为120160 Gy。术后复查随访,统计有效率、局部控制率和生存率,以及副反应等情况。结果：治疗使29人获得了肿瘤完全消退（完全缓解complete remission,CR）,7人消退大于50%（部分缓解partial remission,PR）,4人消退小于50%,2人无效,有效率CR＋PR为83.7%。术后随访时间为848个月,平均21个月,失访1人,局部控制率为79%,总生存率为76.7%,最长无瘤生存已达48个月,未发现严重放疗副反应。结论：对于手术禁忌的患者或无法切除的腺源性肿瘤,放射性粒子组织间植入近距离放疗可以获得较好的近期疗效。Objective： To detect the efficacy of 125I radioactive seeds implanting treating malignant salivary gland tumors.Methods： Forty-three patients with malignant salivary gland tumors of head neck were treated with 125I radioactivity seeds interstitial brachytherapy at Peking University Stomatologic Hospital between 2001 and 2008.These patients were implanted with 125I radioactivity seeds with the dosage of 120 to 160 Gy.The treatment response,local control rate and survival rate were evaluated and the adverse events observed.Results： Twenty-nine patients had complete remission（CR）of their tumors,and seven patients partial remission（PR）,The response rate was 83.7%.The patients were followed up for 8 to 48 months（median 21 months）.The local control rate was 79%,and total survival rate 76.7%.No serious side radiotherapeutic effect was observed.Conclusion： Radioactivity seeds interstitial brachytherapy is an effective form of treatment for patients with unresectable malignant salivary gland tumors.

关 键 词：头颈部肿瘤 近距离放射疗法 治疗结果 

分 类 号：R739.87[医药卫生—肿瘤]