早期胃癌的还氧合酶-2、抑癌基因P16和肝细胞生长因子表达  

Expressions of COX-2、P16 and HGF in gastric cancer with early stage

作　　者：韩玉龙[1] 孙雷[2] 尹家俊[1] 

机构地区：[1]大连大学附属中山医院普外二科,辽宁大连116001 [2]大连医科大学病理学教研室,辽宁大连116044

出　　处：《大连医科大学学报》2011年第2期127-130,共4页Journal of Dalian Medical University

摘　　要：[目的]探讨还氧合酶-2(COX-2)、抑癌基因P16和肝细胞生长因子(HGF)在早期胃癌中表达的意义。[方法]用免疫组化方法检测正常胃黏膜、不典型增生胃黏膜、早期胃癌组织COX-2、P16和HGF蛋白表达情况。[结果]在由正常胃黏膜到不典型增生,再到早期胃癌的演进过程中,COX-2和HGF蛋白表达呈上升趋势,P16蛋白表达呈下降趋势。COX-2、P16和HGF的表达在正常胃黏膜与不典型增生胃黏膜间及不典型增生胃黏膜与早期胃癌组织间差异均有显著性意义;在早期胃癌组织中HGF与P16间及HGF与COX-2间的表达具有明显相关性。[结论]HGF与COX-2表达增高,P16表达降低可能是早期胃癌发生过程中的分子事件。[Objective] Investigate the significance of expressions of COX-2,P16 and HGF in early gastric cancer.[Methods] Expressions of COX-2、P16 and HGF were detected by immunohistochemistry in tissues,of normal gastric mucosa,gastric dysplasia and early gastric cancer.[Results] Through the development of normal gastric mucosa→gastric dysplasia→early gastric cancer,expressions of COX-2 and HGF were increasing,but that of P16 was decreasing.Expressions of COX-2,P16 and HGF among normal gastric mucosa,gastric dysplasia and early gastric cancer were significantly different.In early gastric cancer,the expression of HGF was related to those of P16,and COX-2 significently.[Conclusion] There were increasing expressions of both of COX-2 and HGF,and decreasing expression of P16 in the gastric carcinogenesis at early stage.

关 键 词：早期胃癌 还氧合酶-2 P16 肝细胞生长因子 

分 类 号：R735.2[医药卫生—肿瘤]