检索规则说明:AND代表“并且”;OR代表“或者”;NOT代表“不包含”;(注意必须大写,运算符两边需空一格)
检 索 范 例 :范例一: (K=图书馆学 OR K=情报学) AND A=范并思 范例二:J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual
作 者:敬攀[1] 宋秀华[1] 麻小莉[1] 郑天生[1] 付晔[1] 唐闻捷[2] 何金彩[1]
机构地区:[1]温州医学院附属第一医院睡眠中心,浙江温州325000 [2]温州医学院,浙江温州325035
出 处:《温州医学院学报》2011年第2期103-106,共4页Journal of Wenzhou Medical College
基 金:"十一五"国家科技支撑计划资助项目(2006BAI13B06);国家高科技研究发展计划资助项目(863计划)(2008AA022604)
摘 要:目的:了解治疗轻中度失眠症的安慰剂效应情况及影响此效应的相关因素。方法:运用与乌灵胶囊的外观、重量、气味和口味完全相同的安慰剂对轻中度失眠症受试者进行为期4周的治疗。以匹兹堡睡眠质量指数量表(PSQI)总分和WHO生存质量测定量表简表(WHOQOL-BREF)各领域分数的情况评价治疗效果。以PSQI总分降分率≥25%作为判定产生了安慰剂效应的标准,分析与安慰剂效应相关的因素。结果:与治疗前相比,治疗后PSQI总分平均减少(4.16±3.17)分,差异有统计学意义(P<0.01);WHOQOL-BREF各领域得分在治疗前后差异也有统计学意义(P<0.01)。治疗前后,PSQI总分减分值与病程呈负性相关,与PSQI总分呈正性相关。对安慰剂效应的影响因素分析显示,病程≤6个月比>6个月易出现安慰剂效应,文化程度越高越容易出现安慰剂效应。结论:治疗轻中度失眠症的安慰剂效应明显,安慰剂效应与病程、文化程度存在联系。Objective: To evaluate the efficacy of placebo in adults with mild insomnia and factors correlated with the efficacy.Methods: Adults with mild insomnia were treated with placebo which was same as Wuling capsule for four weeks.The effect was evaluated by scores of Pittsburgh Sleep Quality Index(PSQI)and World Health Organization Quality Of Life-Brief(WHOQOL-BREF).If the score of PSQI descented more than 25%,it was thought that it had placebo effects.Used this standard,the factors correlated with placebo effects were analysed.Results: By four weeks of treatment,the score of PSQI decreased(4.16±3.17)points on average.There was a great significantly decrease compared to baseline(P 〈0.0001).There was also a great significantly improvement in every part of WHOQOL-BREF(P〈 0.0001).The decent of PSQI points was negatively correlated with the course of disease and positively correlated with the point of PSQI.Placebo effects'correlation analysis showed that those who had a less or equal 6 months course of disease or had a higher education were more likely have placebo effects(P〈 0.05).Conclusion: There are significant effects of the placebo for the treatment of mild insomnia.Placebo effects correlate with course of disease and education.
分 类 号:R749.7[医药卫生—神经病学与精神病学]
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在链接到云南高校图书馆文献保障联盟下载...
云南高校图书馆联盟文献共享服务平台 版权所有©
您的IP:216.73.216.33