角膜基质细胞的表型转化及其分子机制  

Phenotype transformation of keratocytes and the molecular mechanism

作　　者：潘红卫[1,2] 李学晶[3] 徐锦堂[1,2] 陈妙姣[4] 马荣[4] 

机构地区：[1]暨南大学医学院眼科研究室,广东广州510632 [2]暨南大学医附属第一医院眼科,广东广州510632 [3]中国中医科学院眼科医院,北京100040 [4]暨南大学医学院临床医学系,广东广州510632

出　　处：《中国病理生理杂志》2011年第4期803-807,812,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81000368);广东省医学科研基金资助项目(No.B2008091);中央高校基本科研业务费专项资金资助项目(No.21609315);暨南大学本科生科技创新工程资助项目(No.cx09100)

摘　　要：角膜瘢痕是继发于多种角膜疾病的病理性改变,是许多角膜疾病造成视力不同程度损害甚至丧失的直接原因,也是影响角膜屈光手术效果的重要因素。对于角膜损伤愈合后的角膜瘢痕,目前临床上主要治疗方法是穿透性或者板层角膜移植术,但因为角膜供体材料缺乏和经济原因,大量的患者无法得到手术治疗而最终丧失视力。近年来国外内相关研究证实了角膜基质细胞向肌成纤维细胞的表型转化在角膜瘢痕形成中的重要作用。Keratocytes,the major cells in corneal stroma,are relatively quiescent and responsible for the maintenance of the extracellular matrix and transparency of the cornea.Under the condition of injury,the keratocytes are activated and transformed to fibroblast and myofibroblast,characterized by alteration in cell morphology,metabolism and functions. This phenotype transformation of keratocytes is closely associated with the corneal scar formation,and its molecular mechanisms have been intensively studied in recent years.Many markers have been found to identify the different phenotypes of keratocytes.Destruction of corneal epithelium,growth factors,PPARγand epigenetic mechanism are,involved in the generation of myofibroblast.

关 键 词：角膜细胞 肌成纤维细胞 表型转化 

分 类 号：R772[医药卫生—眼科]